{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:52:46Z","timestamp":1773035566357,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Public Health Key Discipline Plan","award":["12GWZX0901"],"award-info":[{"award-number":["12GWZX0901"]}]},{"name":"Shanghai Public Health Key Discipline Plan","award":["15GWZK1001"],"award-info":[{"award-number":["15GWZK1001"]}]},{"name":"National Social Science Grant of China","award":["13CSH076"],"award-info":[{"award-number":["13CSH076"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tooth loss contributes physically and psychologically to health, and quality of life has been a key indicator of the cancer survivors. However, it is less clear whether tooth loss has impact on cancer survivors\u2019 quality of life. Our study aimed to investigate the association between tooth loss, toothbrushing, and quality of life in cancer survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted among 9125 cancer survivors in Shanghai, China. Sociodemographic characteristics, frequency of tooth brushing, number of tooth loss were collected using a self\u2010reported questionnaire. Quality of life was measured using the EORTC QLQ\u2010C30. Chi\u2010square test was used to compare the distribution of tooth loss and toothbrushing frequency among various cancer sites, sociodemographic factors, socioeconomic status, health conditions. Multiple linear regression models were performed to estimate the effects of tooth loss and toothbrushing on quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants diagnosed with cancer of oral cavity, pharynx, and nasopharynx reported higher percentage of 11+ tooth loss. Cancer survivors with toothbrushing \u22652 times\/d reported higher scores in physical, cognitive, and social function and had milder nausea and vomiting, compared with ones with toothbrushing &lt;2 times\/d. Tooth loss was associated with milder physical, role and emotional function scores, and severer fatigue, nausea\/vomiting, dyspnea, insomnia, appetite loss, constipation, and diarrhea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to investigate the impact of toothbrushing and tooth loss on quality of life among cancer survivors. Tooth loss was associated with milder physical, role and emotional function scores, and severer fatigue, nausea\/vomiting, dyspnea, insomnia, appetite loss, constipation and diarrhea. Toothbrushing had significant positive effect on cancer survivors\u2019 quality of life. The present study also provided several public health strategies to improve oral health among cancer survivors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.1835","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T03:25:11Z","timestamp":1540956311000},"page":"6374-6384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The association of tooth loss, toothbrushing, and quality of life among cancer survivors"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5330-7861","authenticated-orcid":false,"given":"Rui","family":"Yan","sequence":"first","affiliation":[{"name":"Institute of Clinical Epidemiology, Key Laboratory of Public Health Safety, Ministry of Education, Key Lab of Health Technology Assessment of Ministry of Health, School of Public Health Fudan University Shanghai 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