{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:28:43Z","timestamp":1793359723839,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602668"],"award-info":[{"award-number":["81602668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thyroid cancer (TC) is one of the most commonly seen secondary malignancy in breast cancer (BC) survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A retrospective study was conducted in BC patients in our center from 1999 to 2013. Patients were divided into BC\u2010TC group and BC\u2010alone group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 13\u00a0978 BC patients were identified, among whom 247 (1.8%) had TC. The standardized incidence ratio (SIR) of TC was 4.48 compared with Chinese females, and up to 98.0% of cases were thyroid papillary carcinomas. A family history of malignancy was the only independent risk factor (odds ratio\u00a0=\u00a01.457, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025) for development of TC in patients with BC. We also identified inferior survival in patients with synchronous versus metachronous BC\u2010TC (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.016). Synchronous BC\u2010TC (risk ratio\u00a0=\u00a05.597, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018) was an independent prognostic factor for inferior RFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed high co\u2010occurrence of TC in patients with BC. There might be different mechanisms behind synchronous and metachronous BC\u2010TC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.1856","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T10:46:00Z","timestamp":1543315560000},"page":"6393-6400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association between breast cancer and thyroid cancer: A study based on 13\u00a0978 patients with breast cancer"],"prefix":"10.1002","volume":"7","author":[{"given":"Nai\u2010si","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-2128","authenticated-orcid":false,"given":"Xing\u2010xing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010jun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Clinical Statistics Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Breast Surgery Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1006-8503","authenticated-orcid":false,"given":"Qing\u2010hai","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010mao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Breast Surgery Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010min","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Breast Surgery Fudan University Shanghai 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