{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:27:56Z","timestamp":1790814476104,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T00:00:00Z","timestamp":1389657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since the introduction of screening programs for cervical cancer (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) the incidence has decreased and <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> is discovered at an earlier stage. The purpose of this study was to analyze time trends in age, stage, and histopathology over a 90\u2010year period and to our knowledge this is the largest single institutional series in the literature of invasive cervical carcinoma (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) cases. This is a retrospective study comprising 18,472 women treated for <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> from 1914 until 2004 at Radiumhemmet, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tockholm. The material is part of the international <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> statistics published since 1937 in the League of Nations' Annual Reports, and since 1958 under the patronage of International Federation of Gynecology and Obstetrics (<jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content>). During the 90\u2010year study period, the annual number of cases treated increased to over 400 up until 1965, after which there was a gradual drop to less than 100 cases in 2004. A pronounced shift toward earlier stages at diagnosis was noted. The mean age at diagnosis increased in all stages, predominantly in advanced stages. A reduction in squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) cases and a sixfold increase in the proportion of adenocarcinoma (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>) cases were observed. The mean age at diagnosis for squamous and <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> cases shifted after 1970, when the <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> cases ultimately became 3\u00a0years older than the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> cases in contrast to around 1950 when they were 3\u00a0years younger than the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> cases. The changes in the distribution by age, stage, and histopathology during this 90\u2010year period are probably associated with: improved social conditions and increased access to health care, the introduction of screening programs for <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> in the 1960s, and a change in the risk factors for <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> (changed sexual behavior, introduction of contraceptive pills, and changed smoking habits).<\/jats:p>","DOI":"10.1002\/cam4.187","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T11:57:46Z","timestamp":1389700666000},"page":"284-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Uterine cervix cancer treatment at Radiumhemmet: 90\u00a0years' experience. Time trends of age, stage, and histopathology distribution"],"prefix":"10.1002","volume":"3","author":[{"given":"Kristina","family":"Hellman","sequence":"first","affiliation":[{"name":"Department of Gynecological Oncology Radiumhemmet Solna, Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Cathrin","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Radiumhemmet Solna, Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Folke","family":"Pettersson","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Radiumhemmet Solna, Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.4.244"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90816-T"},{"key":"e_1_2_7_5_1","first-page":"117","volume-title":"Use of screening for cervical cancer. 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