{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:16:29Z","timestamp":1784034989358,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infections with human papillomavirus (HPV) types 16 and 18 account for ~70% of invasive cervical cancers but the degree of protection from naturally acquired anti\u2010HPV antibodies is uncertain. We examined the risk of HPV infections as defined by HPV DNA detection and cervical abnormalities among women &gt;25\u00a0years in the Human Papilloma VIrus Vaccine Immunogenicity ANd Efficacy trial's (VIVIANE, NCT00294047) control arm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum anti\u2010HPV\u201016\/18 antibodies were determined at baseline and every 12\u00a0months in baseline DNA\u2010negative women (N\u00a0=\u00a02687 for HPV\u201016 and 2705 for HPV\u201018) by enzyme\u2010linked immunosorbent assay (ELISA) from blood samples. HPV infections were identified by polymerase chain reaction (PCR) every 6\u2010months, and cervical abnormalities were confirmed by cytology every 12\u00a0months. Data were collected over a 7\u2010year period. The association between the risk of type\u2010specific infection and cervical abnormalities and serostatus was assessed using Cox proportional hazard models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Risk of newly detected HPV\u201016\u2010associated 6\u2010month persistent infections (PI) (hazard ratio [HR]\u00a0=\u00a00.56 [95%CI:0.32; 0.99]) and atypical squamous cells of undetermined significance (ASC\u2010US+) (HR\u00a0=\u00a00.28 [0.12; 0.67]) were significantly lower in baseline seropositive vs baseline seronegative women. HPV\u201016\u2010associated incident infections (HR\u00a0=\u00a00.81 [0.56; 1.16]) and 12\u2010month PI (HR\u00a0=\u00a00.53 [0.24; 1.16]) showed the same trend. A similar trend of lower risk was observed in HPV\u201018\u2010seropositive vs \u2010seronegative women (HR\u00a0=\u00a00.95 [0.59; 1.51] for IIs, HR\u00a0=\u00a00.43 [0.16; 1.13] for 6\u2010month PIs, HR\u00a0=\u00a00.31 [0.07; 1.36] for 12\u2010month PIs, and HR\u00a0=\u00a00.61 [0.23; 1.61] for ASC\u2010US+).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Naturally acquired anti\u2010HPV\u201016 antibodies were associated with a decreased risk of subsequent infection and cervical abnormalities in women &gt;25\u00a0years. This possible protection was lower than that previously reported in 15\u2010 to 25\u2010year\u2010old women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.1879","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T07:38:05Z","timestamp":1562312285000},"page":"4938-4953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Risk of newly detected infections and cervical abnormalities in adult women seropositive or seronegative for naturally acquired HPV\u201016\/18 antibodies"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7230-1978","authenticated-orcid":false,"given":"Dominique","family":"Rosillon","sequence":"first","affiliation":[{"name":"GSK  Wavre Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Baril","sequence":"additional","affiliation":[{"name":"GSK  Wavre Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rowena","family":"Del Rosario\u2010Raymundo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology San Pablo Colleges Medical Center  San Pablo City The Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosette Marie","family":"Wheeler","sequence":"additional","affiliation":[{"name":"University of New Mexico Health Sciences Center  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Rachel","family":"Skinner","sequence":"additional","affiliation":[{"name":"Vaccines Trials Group Telethon Kids Institute  Perth Western Australia Australia"},{"name":"Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne Marie","family":"Garland","sequence":"additional","affiliation":[{"name":"The Royal Women's Hospital, The Royal Children's Hospital, Murdoch Childrens Research Institute University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Salmeron","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social  Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Lazcano\u2010Ponce","sequence":"additional","affiliation":[{"name":"National Institute of Public Health  Cuernavaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Santiago","family":"Vallejos","sequence":"additional","affiliation":[{"name":"Departamento de Oncolog\u00eda M\u00e9dica Oncosalud\u2010AUNA  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Stoney","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"ter Harmsel","sequence":"additional","affiliation":[{"name":"Department of Gynecology Roosevelt Kliniek, Leiden  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy Yong Kuei","family":"Lim","sequence":"additional","affiliation":[{"name":"KK Hospital  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swee Chong","family":"Quek","sequence":"additional","affiliation":[{"name":"ASC Clinic for Women Gleneagles Hospital  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Minkina","sequence":"additional","affiliation":[{"name":"City Clinical Hospital  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly 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