{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:58:39Z","timestamp":1792403919699,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This multi\u2010institutional retrospective study focused on the clinical outcome of carbon\u2010ion radiotherapy (C\u2010ion RT) for non\u2010squamous cell malignant tumors of the nasopharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Japan Carbon\u2010ion Radiation Oncology Study Group collected and analyzed data for 43 patients with non\u2010squamous cell malignant tumors of the nasopharynx treated with C\u2010ion RT at four institutions in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine patients had adenoid cystic carcinomas, seven had malignant melanomas, three had adenocarcinomas, two had mucoepidermoid carcinomas, and two had other pathologies. Twenty\u2010six of the 43 patients (61%) had T4 tumors. The most common dose\u2010fractionation schedule was 64\u00a0Gy (relative biological effectiveness) in 16 fractions. The median follow\u2010up period was 30\u00a0months. The 2\u2010year local control (LC) and overall survival (OS) rates were 88% and 84%, respectively. For late toxicity, one patient developed grade 4 optic nerve disorder and two developed grade 5 pharyngeal hemorrhage. Actual incidence of grade 3 or higher late adverse events was 19%, and included cranial nerve dysfunction, jaw bone necrosis, central nervous system necrosis, and ear inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>C\u2010ion RT provided good LC and OS rates with acceptable toxicity for treatment of non\u2010squamous cell malignant tumors of the nasopharynx.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.1884","type":"journal-article","created":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T23:49:34Z","timestamp":1542584974000},"page":"6077-6083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A multi\u2010institutional retrospective study of carbon\u2010ion radiotherapy for non\u2010squamous cell malignant tumors of the nasopharynx: Subanalysis of Japan Carbon\u2010Ion Radiation Oncology Study Group study 1402 HN"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6209-9446","authenticated-orcid":false,"given":"Takanori","family":"Abe","sequence":"first","affiliation":[{"name":"Gunma University Heavy Ion Medical Center Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ohno","sequence":"additional","affiliation":[{"name":"Gunma University Heavy Ion Medical Center Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Koto","sequence":"additional","affiliation":[{"name":"Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Demizu","sequence":"additional","affiliation":[{"name":"Department of Radiology Hyogo Ion Beam Medical Center Tatsuno Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1574-5510","authenticated-orcid":false,"given":"Hiroaki","family":"Suefuji","sequence":"additional","affiliation":[{"name":"Ion Beam Therapy Center SAGA HIMAT Foundation Tosu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Okimoto","sequence":"additional","affiliation":[{"name":"Department of Radiology Hyogo Ion Beam Medical Center Tatsuno Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Shioyama","sequence":"additional","affiliation":[{"name":"Ion Beam Therapy Center SAGA HIMAT Foundation Tosu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010ichi","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Toyama University Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Saitama Medical Center Jichi Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine Yamagata University Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kamada","sequence":"additional","affiliation":[{"name":"Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Japan Carbon\u2010Ion Radiation Oncology Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2015.03.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.08.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq277"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.60.9347"},{"key":"e_1_2_7_6_1","volume-title":"Diagnostic Histopathology of Tumors","author":"Fletcher C","year":"2013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1201\/b15450"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089161309900229"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.11.016"},{"key":"e_1_2_7_10_1","first-page":"1688","article-title":"A rare case of unresectable adenoid cystic carcinoma of the nasopharynx treated with intensity modulated proton therapy","volume":"9","author":"Phan J","year":"2017","journal-title":"Cureus"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1878-5085-4-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hys104"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13325"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.04.032"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13270"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.12.028"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.11.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13558"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.05.074"},{"key":"e_1_2_7_20_1","unstructured":"US. Department of Health and Human Services National Institutes of Health National Cancer Institute.Common Terminology Criteria for Adverse Events v4.0.2013.https:\/\/evs.nci.nih.gov\/ftp1\/CTCAE\/CTCAE_4.03_2010-06-14_Quick Reference_5x7.pdf#search='NIH+NCI+CTCAE+4'. Accessed March 10 2018."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr432"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq258"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600716"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18713-z"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.08.014"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141734"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.11.005"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.07.298"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-92"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phro.2017.07.003"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.1884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.1884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T06:10:59Z","timestamp":1694758259000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.1884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,18]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/cam4.1884"],"URL":"https:\/\/doi.org\/10.1002\/cam4.1884","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,18]]},"assertion":[{"value":"2018-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}