{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T19:23:59Z","timestamp":1772047439099,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["JK2013A21"],"award-info":[{"award-number":["JK2013A21"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["JK2014B10"],"award-info":[{"award-number":["JK2014B10"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our study presents the genetic landscape betel quid chewing\u2010associated tongue carcinomas (BQ\u2010TCs). We compared the genetic landscape and mutational signatures of 15 BQ\u2010TCs, five nonbetel quid chewing\u2010associated tongue carcinomas (nBQ\u2010TCs), and 82 tongue carcinomas in general population from the TCGA (TCGA\u2010TCs) project. The highlights of this research mainly include: (a) The genetic landscape of BQ\u2010TC was characterized with frequent mutations in RASA1 gene and in CpG islands throughout the genome. (b) The BQ\u2010TC had a distinct mutational signature from that of nBQ\u2010TC and tongue carcinomas in the general population, and this signature was associated with the mutations in RASA1 and in CpG islands. (c) Our study indicates that betel quid (BQ) chewing classifies a distinct group of tongue carcinoma. The BQ chewing might not contribute to the tumorigenesis of tongue carcinomas as a mutagen.<\/jats:p>","DOI":"10.1002\/cam4.1888","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T08:18:08Z","timestamp":1548317888000},"page":"701-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mutational signatures and the genomic landscape of betel quid chewing\u2010associated tongue carcinoma"],"prefix":"10.1002","volume":"8","author":[{"given":"Weilong","family":"Zhang","sequence":"first","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"State Key Lab of Molecular Oncology, National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 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Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"State Key Lab of Molecular Oncology, National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Jiao","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"State Key Lab of Molecular Oncology, National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Laboratory of Cell and Molecular Biology, National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, National Cancer Center\/Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beibei","family":"Yang","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"State Key Lab of Molecular Oncology, National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, National Cancer Center\/Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Xin","family":"Zeng","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Department of Experimental Research, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13556210120091464"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13556210020091437"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"Betel\u2010quid and areca\u2010nut chewing and some areca\u2010nut derived nitrosamines","volume":"85","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2004","journal-title":"IARC Monogr Eval Carcinog Risks 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