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We used information from a population\u2010based study to compare measured risk factors, tumor characteristics, survival, and known mismatch repair (MMR) pathogenic variant status for EC subgroups according to prior diagnosis of cancer (none, breast cancer tamoxifen\u2010treated or not, Lynch Syndrome (LS)\u2010associated cancer). Family history of any cancer was increased for EC cases with prior breast cancer, both tamoxifen treated (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) and untreated (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). EC cases with prior LS\u2010associated cancer more often reported family history of LS\u2010associated cancer (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) and breast cancer (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05). EC patients with a germline pathogenic MMR gene variant were more likely to report a prior cancer than cases with a MMR proficient tumor (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001), but more than half (54.5%) of MMR carriers reported no prior cancer. Women developing EC after tamoxifen treatment for breast cancer were significantly more likely to develop EC of malignant mixed mullerian tumor subtype (13.2% vs 2.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.3\u00a0\u00d7\u00a010<jats:sup>\u22126<\/jats:sup>), present with stage IV disease (8.8% vs 1.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.6\u00a0\u00d7\u00a010<jats:sup>\u22126<\/jats:sup>), and have poorer survival (HR<jats:sub>adj<\/jats:sub> 1.96; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). While report of prior cancer is an indicator of MMR pathogenic variant status, molecular analysis of all ECs at diagnosis is warranted to detect all patients with LS. Results also indicate the importance of longer\u2010term monitoring of women treated with tamoxifen for symptoms of EC, and the need for studies assessing the biological mechanism underlying the poorer prognosis of this subset of EC patients.<\/jats:p>","DOI":"10.1002\/cam4.1890","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T17:53:51Z","timestamp":1543427631000},"page":"6411-6422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk and prognostic factors for endometrial carcinoma after diagnosis of breast or Lynch\u2010associated cancers\u2014A population\u2010based analysis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7888-1966","authenticated-orcid":false,"given":"Sharon E.","family":"Johnatty","sequence":"first","affiliation":[{"name":"Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin J. R.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Histopathology King Edward Memorial Hospital Perth Western Australia Australia"},{"name":"School of Woman's and Infants' Health University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pathology The Mater Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-6675","authenticated-orcid":false,"given":"Daniel","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology The University of Melbourne Parkville Victoria Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne Melbourne 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope M.","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Population Health QIMR Berghofer Medical Research Institute Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-7897","authenticated-orcid":false,"given":"Amanda B.","family":"Spurdle","sequence":"additional","affiliation":[{"name":"Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute Brisbane Queensland 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