{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:04:47Z","timestamp":1785542687318,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The phase III VELOUR trial demonstrated efficacy with combined FOLFIRI\u2010aflibercept in patients with metastatic colorectal cancer previously treated with oxaliplatin with or without bevacizumab versus placebo. The effect of FOLFIRI\u2010aflibercept in routine clinical practice was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Patients<\/jats:title><jats:p>Overall survival (OS), progression\u2010free survival (PFS), response and safety were analysed for 78 patients treated with FOLFIRI\u2010aflibercept at six GITuD institutions. Exploratory analyses of prognostic and predictive markers of efficacy were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients had good general status (PS 0\u20101 96.2%), tumours were mostly <jats:italic>RAS<\/jats:italic>\u2010mutant (75.6%), synchronous (71.8%), and left\u2010sided (71.8%). Prior therapy included bevacizumab (47.4%) and anti\u2010EGFR agents (12.8%). PFS was longer for metachronous than synchronous tumours (11.0 vs 5.0\u00a0months, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028), and for left\u2010colon tumours (7.0 vs 3.0\u00a0months, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.044). <jats:italic>RAS\u2010<\/jats:italic>mutant status, first\u2010line treatment and primary tumour surgery did not impact PFS. The disease control rate was 70.5%. The most common grade 3\/4 toxicities were neutropenia (15.3%), asthenia (10.3%), diarrhea and mucositis (6.4% each). Dysphonia was reported in 39.7% of patients, and grade 3 hypertension in 3.8%. Development of hypertension (any grade) was significantly associated with a reduced risk of progression by multivariate analysis (HR\u00a0=\u00a02.7; 95%CI 1.3\u20105.4; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Efficacy with FOLFIRI\u2010aflibercept in a real\u2010life population was in line with results from the pivotal trial and toxicity was manageable with treatment adaptation. Survival outcomes were not impacted by primary tumour location, <jats:italic>RAS<\/jats:italic>\u2010mutant status, first\u2010line treatment or primary tumour surgery. Hypertension may be a surrogate marker of efficacy in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.1903","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T23:32:56Z","timestamp":1548718376000},"page":"882-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Efficacy and safety of FOLFIRI\/aflibercept in second\u2010line treatment of metastatic colorectal cancer in a real\u2010world population: Prognostic and predictive markers"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4630-5830","authenticated-orcid":false,"given":"Ana","family":"Fern\u00e1ndez Montes","sequence":"first","affiliation":[{"name":"University Hospital of Ourense Ourense Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieves","family":"Mart\u00ednez Lago","sequence":"additional","affiliation":[{"name":"University Hospital of A 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