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In the period directly following transplantation, several factors may contribute to complications that lead to the activation or damage of endothelial cells, involved in the pathogenesis of vascular endothelial syndromes (<jats:styled-content style=\"fixed-case\">VES<\/jats:styled-content>). However, to date, sufficiently specific and sensitive diagnostic markers for the various forms of <jats:styled-content style=\"fixed-case\">VES<\/jats:styled-content> have not been identified. This was a retrospective single\u2010center study of patients who underwent allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. For this cohort of patients, parameters including type of engraftment, donor characteristics, and cytokine production were measured and correlated with a high prevalence of short\u2010term complications after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. The aim of this study was to identify specific parameters useful for improving diagnostics and predicting adverse effects in <jats:styled-content style=\"fixed-case\">VES<\/jats:styled-content>. We confirmed that monocyte\u2010predominant engraftment was related to a higher risk for an early transplant\u2010related complication termed sinusoidal obstruction syndrome (<jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>). The increased production of specific cytokines, in particular <jats:styled-content style=\"fixed-case\">RANTES<\/jats:styled-content>, represents a marker associated with prevalent engraftment. In addition, patients undergoing prophylaxis with defibrotide had \u201cclassical\u201d engraftment, a common cytokine profile and a lower incidence of life\u2010threatening transplant\u2010related complications. The beneficial effect of defibrotide might be a starting point for developing selective prophylaxis for patients with monocyte engraftment to prevent severe early transplant\u2010related complications.<\/jats:p>","DOI":"10.1002\/cam4.1912","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T23:36:36Z","timestamp":1548718596000},"page":"890-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Monocyte\u2010predominant engraftment, cytokine levels and early transplant\u2010related complications in pediatric hematopoietic stem cell recipients"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-1875","authenticated-orcid":false,"given":"Natalia","family":"Maximova","sequence":"first","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"},{"name":"Clinical Epidemiology and Public Health 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