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Microarray analysis was conducted to search the NPC\u2010related differentially expressed genes (DEGs) and predict the miRs regulating PBK, which suggested that miR\u2010372 could influence the development of NPC via PBK and the p53 signaling pathway. Importantly, miR\u2010372 was observed to target PBK, thus down\u2010regulating its expression. Then, NPC 5\u20108F and C666\u20101 cells were selected, and treated with ionization radiation and alteration of miR\u2010372 and PBK expression to explore the functional role of miR\u2010372 in NPC. The expression of miR\u2010372, PBK, Bcl\u20102, p53, and Bax as well as the extent of Akt phosphorylation were measured. In addition, cell colony formation, cell cycle, proliferation, apoptosis, migration, and invasion were detected. At last, tumor growth and the effect of miR\u2010372 on radiosensitivity of NPC were evaluated. Besides, over\u2010expressed miR\u2010372 down\u2010regulated Bcl\u20102 and PBK expression and the extent of Akt phosphorylation while up\u2010regulated the expression of p53 and Bax. Additionally, miR\u2010372 over\u2010expression and radiotherapy inhibited cell clone formation, proliferation, tumor growth, migration, invasion, and cell cycle entry, but promoted cell apoptosis. However, the restoration of PBK in NPC cells expressing miR\u2010372 reversed the anti\u2010tumor effect of miR\u2010372 and activation of the p53 signaling pathway. In conclusion, the study shows that up\u2010regulated miR\u2010372 promotes radiosensitivity by activating the p53 signaling pathway via inhibition of PBK.<\/jats:p>","DOI":"10.1002\/cam4.1924","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T09:18:21Z","timestamp":1547803101000},"page":"712-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["MicroRNA\u2010372 enhances radiosensitivity while inhibiting cell invasion and metastasis in nasopharyngeal carcinoma through activating the PBK\u2010dependent p53 signaling pathway"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1522-4475","authenticated-orcid":false,"given":"Zhe","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Affiliated Zhongshan Hospital of Dalian University Dalian China"},{"name":"The Key Laboratory of Biomarker High Throughput Screening 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