{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:51:35Z","timestamp":1762980695184,"version":"3.40.5"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>No data are available regarding obesity and outcome in Chronic Lymphocytic Leukemia (CLL). We analyzed 263 patients from the AGMT CLL\u20108a Mabtenance trial for the impact of obesity. The trial included patients after rituximab\u2010containing induction treatment in first or second line that had achieved at least a PR. A randomization to rituximab maintenance treatment (375\u00a0mg\/m<jats:sup>2<\/jats:sup> q3 months for 2\u00a0years) vs observation was performed. In this cohort 22% of the patients (58\/263) were classified as obese. The baseline response to induction treatment was inferior in obese patients with a lower CR rate (43.1% vs 60.5% in obese vs non\u2010obese, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018) and with a lower rate of patients achieving MRD negativity after chemoimmunotherapy induction treatment (19.6% vs 35.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). The PFS outcome of obese patients was significantly worse in the observation group of the trial (24 vs 39\u00a0months median PFS, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). However, in the rituximab maintenance group the outcome for obese vs non\u2010obese was not different (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.4). In summary, obesity was overall associated with a worse outcome of chemoimmunotherapy induction. However, rituximab maintenance treatment seems to be able to overcome this negative effect.<\/jats:p>","DOI":"10.1002\/cam4.1980","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T02:53:30Z","timestamp":1553050410000},"page":"1401-1405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rituximab maintenance overcomes the negative prognostic factor of obesity in CLL: Subgroup analysis of the international randomized AGMT CLL\u20108a mabtenance trial"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0648-4416","authenticated-orcid":false,"given":"Alexander","family":"Egle","sequence":"first","affiliation":[{"name":"Third Medical Department Paracelsus Medical University Salzburg Salzburg Austria"},{"name":"Salzburg Cancer Research Institute (SCRI) Salzburg Austria"},{"name":"Cancer Cluster Salzburg (CCS) Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Melchardt","sequence":"additional","affiliation":[{"name":"Third Medical Department Paracelsus Medical University Salzburg Salzburg Austria"},{"name":"Salzburg Cancer Research Institute (SCRI) Salzburg Austria"},{"name":"Cancer Cluster Salzburg (CCS) Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Obrtl\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"First Faculty of Medicine Charles University in Prague and General University Hospital in Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luk\u00e1\u0161","family":"Smolej","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine \u2010 Hematology, Faculty of Medicine in Hradec Kr\u00e1lov\u00e9 University Hospital and Charles University in Prague Hradec Kr\u00e1lov\u00e9 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Koz\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2010 Hematology University Hospital Kralovske Vinohrady Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Steurer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Medical University Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Andel","sequence":"additional","affiliation":[{"name":"Internal Medicine II Hospital of Steyr Steyr Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Burgstaller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV Klinikum Wels\u2010Grieskirchen GmbH Wels 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