{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:12Z","timestamp":1786977132205,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2016HM58"],"award-info":[{"award-number":["ZR2016HM58"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>\n \n Visceral pleural invasion (\n VPI<\/jats:styled-content>\n ) has been identified as an adverse prognostic factor for non\u2010small cell lung cancer (\n NSCLC<\/jats:styled-content>\n ). Accurate nodal staging for\n NSCLC<\/jats:styled-content>\n correlates with improved survival, but it is unclear whether tumors with\n VPI<\/jats:styled-content>\n require a more extensive lymph nodes (\n LN<\/jats:styled-content>\n s) dissection to optimize survival. We aimed to evaluate the impact of\n VPI<\/jats:styled-content>\n status on the optimal extent of\n LN<\/jats:styled-content>\n s dissection in stage I\n NSCLC<\/jats:styled-content>\n , using the Surveillance, Epidemiology, and End Results (\n SEER<\/jats:styled-content>\n ) database. We identified 9297 surgically treated T1\u20102aN0M0\n NSCLC<\/jats:styled-content>\n patients with at least one examined\n LN<\/jats:styled-content>\n s. Propensity score matching was conducted to balance the baseline clinicopathologic characteristics between the\n VPI<\/jats:styled-content>\n group and non\u2010\n VPI<\/jats:styled-content>\n group. Log\u2010rank tests along with Cox proportional hazards regression methods were performed to evaluate the impact of extent of\n LN<\/jats:styled-content>\n s dissection on survival.\n VPI<\/jats:styled-content>\n was correlated with a significant worse survival, but there was no significant difference in survival rate between\n PL<\/jats:styled-content>\n 1 and\n PL<\/jats:styled-content>\n 2. Patients who underwent sublobectomy had slightly decreased survival than those who underwent lobectomy. Pathologic\n LN<\/jats:styled-content>\n s examination was significantly correlated with survival. Examination of 7\u20108\n LN<\/jats:styled-content>\n s and 14\u201016\n LN<\/jats:styled-content>\n s conferred the lowest hazard ratio for T1\u2010sized\/non\u2010\n VPI<\/jats:styled-content>\n tumors (stage\n IA<\/jats:styled-content>\n ) and T1\u2010sized\/\n VPI<\/jats:styled-content>\n tumors (stage\n IB<\/jats:styled-content>\n ), respectively. The optimal extent of\n LN<\/jats:styled-content>\n s dissection varied by\n VPI<\/jats:styled-content>\n status, with T1\u2010sized\/\n VPI<\/jats:styled-content>\n tumors (stage\n IB<\/jats:styled-content>\n ) requiring a more extensive\n LN<\/jats:styled-content>\n s dissection than T1\u2010sized\/non\u2010\n VPI<\/jats:styled-content>\n tumors (stage\n IA<\/jats:styled-content>\n ). These results might provide guidelines for surgical procedure in early stage\n NSCLC<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1002\/cam4.1990","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T07:58:24Z","timestamp":1549007904000},"page":"669-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Impact of visceral pleural invasion on the association of extent of lymphadenectomy and survival in stage I non\u2010small cell lung cancer"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-8860","authenticated-orcid":false,"given":"Yang","family":"Wo","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuncheng","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Affiliated Hospital of Qingdao University Qingdao 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