{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:23:47Z","timestamp":1780723427961,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,3]],"date-time":"2012-06-03T00:00:00Z","timestamp":1338681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Today, most oropharyngeal squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>) is human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) positive and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> alone or in combination with <jats:styled-content style=\"fixed-case\">p16<\/jats:styled-content> is reported to be a favorable prognostic factor for <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>. Patients with tumors at other <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> sites (<jats:styled-content style=\"fixed-case\">OOSCC<\/jats:styled-content>) are often included in the same treatment and study protocols as patients with tonsillar\u2010 and base of tongue <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>, even though the prevalence and clinical significance of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection in <jats:styled-content style=\"fixed-case\">OOSCC<\/jats:styled-content> is unknown. Since tonsillar and base of tongue <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content> cover roughly 90% of all <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>, there is an obvious risk that there may be a misinterpretation of the results for <jats:styled-content style=\"fixed-case\">OOSCC<\/jats:styled-content>. Herein, we therefore study the prevalence of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">p16<\/jats:styled-content> and their impact on survival in <jats:styled-content style=\"fixed-case\">OOSCC<\/jats:styled-content>. A total of 69 patients were included in the study, and 61 were included in the survival analysis. <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">p16<\/jats:styled-content> were present in only 17% (12\/69) and 25% (17\/69) of the <jats:styled-content style=\"fixed-case\">OOSCC<\/jats:styled-content> cases, respectively, while the majority 69% (48\/69) was both <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">p16<\/jats:styled-content> negative. Neither <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> nor <jats:styled-content style=\"fixed-case\">p16<\/jats:styled-content> had predictive value for clinical outcome in <jats:styled-content style=\"fixed-case\">OOSCC<\/jats:styled-content> in this study. In conclusion, the prevalence of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">p16<\/jats:styled-content> is much lower in <jats:styled-content style=\"fixed-case\">OOSCC<\/jats:styled-content> compared to earlier reports including all <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>, or tonsillar\u2010 and base of tongue cancer alone and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">p16<\/jats:styled-content> had no impact on clinical outcome in <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> in this study. Our data highlight the diversity of head neck cancer sub\u2010sites and the importance of taking <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> sub\u2010sites in consideration in future clinical trials and treatment.<\/jats:p>","DOI":"10.1002\/cam4.2","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T16:26:22Z","timestamp":1338827182000},"page":"82-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer"],"prefix":"10.1002","volume":"1","author":[{"given":"Linda","family":"Marklund","sequence":"first","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Department of Oto\u2010Rhino\u2010Laryngology, Head and Neck Surgery Karolinska University Hospital, Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"N\u00e4sman","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f6rn","family":"Ramqvist","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Dalianis","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Munck\u2010Wikland","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Department of Oto\u2010Rhino\u2010Laryngology, Head and Neck Surgery Karolinska University Hospital, Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalle","family":"Hammarstedt","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Department of Oto\u2010Rhino\u2010Laryngology, Head and Neck Surgery Karolinska University Hospital, Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.09.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22963"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20998"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480601110170"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24994"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24339"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1611.100452"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_7_11_1","first-page":"1829","article-title":"Presence of human papillomavirus in tonsillar cancer is a favourable prognostic factor for clinical outcome","volume":"24","author":"Dahlstrand H.","year":"2004","journal-title":"Anticancer Res."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2007.08.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.04.012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25625"},{"key":"e_1_2_7_16_1","first-page":"72","article-title":"Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival","volume":"62","author":"Wittekindt C.","year":"2005","journal-title":"Adv. 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