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As the nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:italic>\u03ba<\/jats:italic>B) pathway contributes to malignant transformation of various types of cells, we explored <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:italic>\u03ba<\/jats:italic>B activity in three different pathological types of malignant mesothelioma cells, and evaluated the therapeutic potential of a recently reported <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:italic>\u03ba<\/jats:italic>B inhibitor, <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>\u20100354. <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:italic>\u03ba<\/jats:italic>B was constantly activated in <jats:styled-content style=\"fixed-case\">MSTO<\/jats:styled-content>\u2010211H, <jats:styled-content style=\"fixed-case\">NCI<\/jats:styled-content>\u2010H28, and <jats:styled-content style=\"fixed-case\">NCI<\/jats:styled-content>\u2010H2052 cells, and the proliferation of these cell lines was inhibited by <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>\u20100354. D\u2010type cyclins were effectively suppressed in mixed tissue type <jats:styled-content style=\"fixed-case\">MSTO<\/jats:styled-content>\u2010211H, leading to cell cycle arrest at sub G<jats:sub>1<\/jats:sub>\/G<jats:sub>1<\/jats:sub> phase. <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>\u20100354 reduced cyclin D3 in both epithelial tissue type <jats:styled-content style=\"fixed-case\">NCI<\/jats:styled-content>\u2010H28 and sarcomatoid tissue type <jats:styled-content style=\"fixed-case\">NCI<\/jats:styled-content>\u2010H2052. In a sphere formation assay, <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>\u20100354 effectively decreased the number and diameter of <jats:styled-content style=\"fixed-case\">MSTO<\/jats:styled-content>\u2010211H spheres. Preincubation of <jats:styled-content style=\"fixed-case\">MSTO<\/jats:styled-content>\u2010211H cells with <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>\u20100354 delayed tumor formation in transplanted immunodeficient mice. Furthermore, administration of <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>\u20100354 markedly rescued the survival rate of mice that received intrathoracic injections of <jats:styled-content style=\"fixed-case\">MSTO<\/jats:styled-content>\u2010211H cells. These results indicate that a targeted drug against <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:italic>\u03ba<\/jats:italic>B might have therapeutic efficacy in the treatment of human malignant mesothelioma.<\/jats:p>","DOI":"10.1002\/cam4.202","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T07:26:45Z","timestamp":1392017205000},"page":"416-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A molecular targeting against nuclear factor\u2010<i>\u03ba<\/i>B, as a chemotherapeutic approach for human malignant mesothelioma"],"prefix":"10.1002","volume":"3","author":[{"given":"Sho","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"},{"name":"Laboratory of Comparative Animal Medicine Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Molecular Pathology and Therapeutics Division of Animal Life Science Institute of Agriculture Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Oida","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyosun","family":"Jang","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungsook","family":"Jung","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Animal Medicine Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Amagai","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Animal Medicine Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Molecular Pathology and Therapeutics Division of Animal Life Science Institute of Agriculture Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Ishizaka","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"},{"name":"Laboratory of Veterinary Molecular Pathology and Therapeutics Division of Animal Life Science Institute of Agriculture Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050152"},{"key":"e_1_2_7_3_1","first-page":"70","article-title":"Mesothelioma: a review","volume":"12","author":"Frank E. 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