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The primary outcomes were symptom response rates. Secondary outcomes included overall survival, adverse events and proportion of patients with \u226510\u2010point absolute improvement in the fatigue, nausea\/vomiting and pain subscales in the <jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content> Qualify of Life Questionnaire C30 (<jats:styled-content style=\"fixed-case\">EORTC QLQ<\/jats:styled-content>\u2010C30) and dysphagia\/pain subscales in the gastric specific module (<jats:styled-content style=\"fixed-case\">STO<\/jats:styled-content>22) at the end of <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> and 1\u00a0month after the completion of radiotherapy. Fifty patients were accrued. Median survival duration was 85\u00a0days. 40\/50 patients (80%) with bleeding, 2\/2 (100%) patients with obstruction and 1\/1 (100%) patient with pain responded to radiotherapy. Improvements fatigue, nausea\/vomiting and pain subscales of the <jats:styled-content style=\"fixed-case\">EORTC QLQ<\/jats:styled-content>\u2010C30 was seen in 50%, 28% and 44% of patients at the end of <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> and in 63%, 31% and 50% of patients 1\u00a0month after <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>. Improvements in dysphagia\/pain subscales of the <jats:styled-content style=\"fixed-case\">STO<\/jats:styled-content>22 was seen in 42% and 28% of patients at then end of <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> and 44% and 19% of patients 1\u00a0month after <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>. Two patients (5%) had grade 3 anorexia and gastritis. Palliative gastric radiotherapy was effective, well tolerated and resulted in improvement in fatigue, dysphagia and pain at the end of radiotherapy and 1\u00a0month after the completion of radiotherapy in a significant proportion of patients.<\/jats:p>","DOI":"10.1002\/cam4.2021","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T05:28:30Z","timestamp":1550726910000},"page":"1447-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase <scp>II<\/scp> trial"],"prefix":"10.1002","volume":"8","author":[{"given":"Jeremy","family":"Tey","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Registry of Diseases Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Y.","family":"Soon","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng N.","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee Y.","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy B. 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