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In a population\u2010based case\u2013control study conducted in Southern China between 2010 and 2014, self\u2010reported height, weight, and body shape at age 20 and 10\u00a0years before interview were collected from 2448 histopathologically confirmed <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> cases and 2534 population\u2010based controls. Body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) was categorized according to the World Health Organization guidelines for Asian populations: underweight (&lt;18.5\u00a0kg\/m<jats:sup>2<\/jats:sup>), normal weight (18.5\u201022.9\u00a0kg\/m<jats:sup>2<\/jats:sup>), overweight (23.0\u201027.4\u00a0kg\/m<jats:sup>2<\/jats:sup>), and obese (\u226527.5\u00a0kg\/m<jats:sup>2<\/jats:sup>). Multivariate odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) with 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were estimated using logistic regression. Furthermore, restricted cubic spline analysis was employed to examine nonlinear effects of <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and body shape as continuous covariates. Underweight vs normal weight at age 20\u00a0years was associated with a 22% decreased <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> risk (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 0.78; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.67, 0.90), whereas obesity was not significantly associated with <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> risk. Associations with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 10\u00a0years before the interview were similar. Having the leanest body shape at age 20\u00a0years, compared with the mode was not significantly associated with <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> risk (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 0.85; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.62, 1.16), but having a larger body shape was associated with an elevated risk (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.25; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.03, 1.52). Increasing <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> revealed positive trends with <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> risk. Despite some indication of significant findings, evidence for a strong association between <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> or body shape and <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> risk is still limited.<\/jats:p>","DOI":"10.1002\/cam4.2027","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T06:19:40Z","timestamp":1550816380000},"page":"1835-1844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Body mass index, body shape, and risk of nasopharyngeal carcinoma: A population\u2010based case\u2013control study in Southern China"],"prefix":"10.1002","volume":"8","author":[{"given":"Ruimei","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Cancer Prevention Center Sun Yat\u2010sen University Cancer Center Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen T.","family":"Chang","sequence":"additional","affiliation":[{"name":"Health Sciences Practice Exponent, Inc. Menlo Park California"},{"name":"Stanford Cancer Institute Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention Center Sun Yat\u2010sen University Cancer Center Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonglin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Wuzhou Red Cross Hospital Wuzhou 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