{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:12:23Z","timestamp":1783469543991,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010246","name":"Postdoctoral Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["2018K090B"],"award-info":[{"award-number":["2018K090B"]}],"id":[{"id":"10.13039\/501100010246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20170623"],"award-info":[{"award-number":["BK20170623"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572457"],"award-info":[{"award-number":["81572457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702442"],"award-info":[{"award-number":["81702442"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872042"],"award-info":[{"award-number":["81872042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Colorectal signet ring cell carcinoma (SRCC) is a rare histological subtype of colorectal adenocarcinoma with high metastatic frequency compared to non\u2010SRCC colorectal cancer (NOS). The aim of this study was to analyze prognostic factors of colorectal SRCC with different metastatic sites and evaluate impacts of various therapies for metastatic colorectal SRCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with NOS and SRCC were from the Surveillance, Epidemiology, and End Results (SEER) database during 2010\u20102014. \u03c7<jats:sup>2<\/jats:sup> tests were used to compare data significance. Kaplan\u2010Meier and COX models were used to analyze the differences in the survival. Propensity\u2010matched analyses were used to adjust numerical differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 173\u00a0460 patients, 1932 (1.11%) patients had colorectal SRCC. In univariate analysis, older age, male sex, and peritoneum metastasis were associated with higher mortality risk. The peritoneum was both the site with the highest metastatic frequency and the site with the worst prognosis in SRCC. In the COX regression model, peritoneum\u2010metastatic SRCC patients receiving chemotherapy had better survival than patients treated with surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study analyzed the unique metastatic pattern of colorectal SRCC toward different sites and found that compared to surgery, chemotherapy was associated with better survival for colorectal SRCC patients with distant metastasis, which provided insights for future SRCC patient treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2054","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T06:38:07Z","timestamp":1552459087000},"page":"1930-1940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Chemotherapy is associated with increased survival from colorectal signet ring cell carcinoma with distant metastasis: A Surveillance, Epidemiology, and End Results database analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9825-3983","authenticated-orcid":false,"given":"Tao","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Nanjing Clinical School of Southern Medical University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Nanjing Clinical School of Southern Medical University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Nanjing Clinical School of Nanjing Medical University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8961-3214","authenticated-orcid":false,"given":"Zengjie","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People\u2019s Republic of China"},{"name":"Department of Medical Oncology Jinling Hospital, Nanjing Clinical School of Southern Medical University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital, Medical School of Nanjing University Nanjing, Jiangsu Province People\u2019s Republic of China"},{"name":"Department of Medical Oncology Jinling Hospital, Nanjing Clinical School of Southern Medical University Nanjing, Jiangsu Province People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21286"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1951.01250030082009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-010-1037-z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt591"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28981"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.025"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182851e2b"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000437899.28701.03"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45334"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.59.7633"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-017-0874-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1179\/0001551213z.0000000002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29049"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24437"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4159-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-009-4057-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2321-7"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.11.005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/dcr.0000000000000318"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28099"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.09.125"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23784"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.1000-9604.2013.01.05"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.12.041"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9073-7"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841860903081897"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.2054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.2054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.2054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.2054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T21:14:03Z","timestamp":1704230043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.2054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/cam4.2054"],"URL":"https:\/\/doi.org\/10.1002\/cam4.2054","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]},"assertion":[{"value":"2018-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}