{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:57:50Z","timestamp":1793656670801,"version":"4.5.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007075","name":"European Society for Medical Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>A substantial proportion of cancer survivors experience fatigue after diagnosis. Physical activity (PA) can impact fatigue after cancer. In this study, we evaluated the prevalence and association of fatigue and the practice of PA in a population with early cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the national population\u2010based French cross\u2010sectional study <jats:italic>Vie apr\u00e8s le cancer 2<\/jats:italic>, we included 1984 patients with early breast (61.1%), prostate (21.5%), and colorectal (17.4%) cancer. Severe fatigue at 2 years postdiagnosis was defined by a score \u226540 in the European Organization for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ C30) fatigue subscale. PA was defined as (a) self\u2010reported PA before diagnosis (active\/inactive) and (b) change in PA since diagnosis (increased\/maintained exposure vs decreased exposure\/remaining inactive). Multivariate regression examined associations of\u00a0severe fatigue with PA, adjusting for baseline clinical and treatment variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 52\u00a0years. 51.5% of patients experienced severe fatigue 2\u00a0years post\u2010diagnosis. 87.7% reported to be physically active before cancer diagnosis; 53.3% of patients either decreased PA or remained inactive at 2\u00a0years postdiagnosis. At 2\u00a0years postdiagnosis, severe fatigue was associated with a change in PA since diagnosis: patients with decreasing PA\/remaining inactive from pre\u2010 to postdiagnosis had a higher risk of severe fatigue vs those with increasing\/maintaining PA (adjusted odds ratio [95% confidence interval] 2.32 [1.85\u20102.90]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fatigue continues to be a substantial problem for cancer survivors 2\u00a0years after cancer diagnosis and is associated with PA decreasing\/remaining inactive since diagnosis. Interventions to maintain or increase PA for cancer survivors should be tested to mitigate long\u2010term fatigue after cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2060","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T06:34:34Z","timestamp":1552458874000},"page":"2535-2544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Fatigue and physical activity in cancer survivors: A cross\u2010sectional population\u2010based study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-9029","authenticated-orcid":false,"given":"Margarida","family":"Matias","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Gustave Roussy, Universit\u00e9 Paris\u2010Sud, Universit\u00e9 Paris\u2010Saclay Villejuif 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