{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T18:25:25Z","timestamp":1781375125305,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2016-12M-1-001"],"award-info":[{"award-number":["2016-12M-1-001"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006739","name":"Capital Foundation of Medical Development","doi-asserted-by":"publisher","award":["2016-2-4016"],"award-info":[{"award-number":["2016-2-4016"]}],"id":[{"id":"10.13039\/501100006739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral T\u2010cell lymphoma (PTCL) is a heterogeneous disease with poor outcomes. We intend to explore the role of circulating PD\u20101 (+) cells in tumor immune evasion in PTCL patients and the mechanism of chidamide as a regulator of immune\u2010associated medicine on PD\u20101 (+) cells. Gene expression profiling (GEP) was performed on circulating PD\u20101 (+) cells from 22 PTCL patients and 13 healthy subjects, and circulating PD\u20101 (\u2212) cells from 2 PTCL patients. PD\u20101 (+) cells were treated with chidamide, and the production IFN\u2010\u03b3 and cytotoxicity were analyzed. GEP were performed on circulating PD\u20101 (+) cells from 2 PTCL patients treated with chidamide combined with chemotherapy and 1 patient treated with traditional chemotherapy. GEP showed that genes associated with innate immune response were abnormally expressed in PD\u20101 (+) cells of PTCL patients compared with healthy subjects, meanwhile the expression of CTLA\u20104 was significantly higher in PD\u20101 (+) cells than that of PD\u20101 (\u2212) cells. In vitro study revealed decreased level of IFN\u2010\u03b3 secretion and impaired cytotoxic activity of PD\u20101 (+) cells compared with PD\u20101 (\u2212) cells, while chidamide could recover the deficiencies and upregulate adaptive immune\u2010associated genes in PD\u20101 (+) cells of PTCL patients. Our research indicated that PD\u20101 (+) cells might have deficiencies in innate and adaptive immune response and chidamide may reverse the defects.<\/jats:p>","DOI":"10.1002\/cam4.2097","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T09:50:45Z","timestamp":1554889845000},"page":"2104-2113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Circulating PD\u20101 (+) cells may participate in immune evasion in peripheral T\u2010cell lymphoma and chidamide enhance antitumor activity of PD\u20101 (+) cells"],"prefix":"10.1002","volume":"8","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4330-850X","authenticated-orcid":false,"given":"Haorui","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-4896","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing P.R. 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