{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:38:14Z","timestamp":1783543094576,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000869","name":"Susan G. Komen for the Cure","doi-asserted-by":"publisher","award":["SAC150061"],"award-info":[{"award-number":["SAC150061"]}],"id":[{"id":"10.13039\/100000869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RO160674"],"award-info":[{"award-number":["RO160674"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The influence of serious mental illness (SMI) on the treatment and survival of patients with high\u2010grade prostate cancer is not well understood. We compared the initial cancer treatment and cancer\u2010specific mortality of SEER\u2010Medicare patients with locoregional high\u2010grade (nonmetastatic) prostate cancer with and without preexisting SMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified SEER\u2010Medicare patients who were 67\u00a0years of age or older diagnosed between 2006 and 2013 with locoregional high\u2010grade (nonmetastatic) prostate cancer. Preexisting SMI was identified by claims indicative of bipolar disorder, schizophrenia, and other psychotic disorder, during the 2\u00a0years before cancer diagnosis. We used multivariable binary logistic regression to examine associations between SMI and receipt of surgery or radiation concurrent with hormone therapy (definitive initial treatment) within 1\u00a0year after cancer diagnosis. We used Kaplan\u2010Meier survival curves, as well as Cox proportional hazards and competing risk models to evaluate unadjusted and adjusted associations between SMI and 5\u2010year cancer\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 49\u00a0985 patients with locoregional high\u2010grade (nonmetastatic) prostate cancer, 523 (1.1%) had SMI and 49\u00a0462 (98.9%) had no SMI. Overall, SMI was associated with reduced odds of receiving surgery (OR\u00a0=\u00a00.66, 95% CI: 0.49\u20100.89) or radiation concurrent with hormone therapy (OR\u00a0=\u00a00.81, 95% CI: 0.67\u20100.98) as initial treatments in the year after cancer diagnosis. Additionally, SMI was associated with higher hazard of 5\u2010year cancer\u2010specific death (HR\u00a0=\u00a01.41, 95% CI: 1.06\u20101.89) after accounting for competing risks of non\u2010cancer death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among SEER\u2010Medicare patients with locoregional high\u2010grade (nonmetastatic) prostate cancer, those with preexisting SMI\u2014relative to those without these conditions\u2014were less likely to receive definitive initial treatment in the year after diagnosis and had poorer cancer\u2010specific survival 5\u00a0years after diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2109","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T02:54:29Z","timestamp":1554346469000},"page":"2612-2622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Impact of serious mental illness on the treatment and mortality of older patients with locoregional high\u2010grade (nonmetastatic) prostate cancer: retrospective cohort analysis of 49\u00a0985 SEER\u2010Medicare patients diagnosed between 2006 and 2013"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-0758","authenticated-orcid":false,"given":"Dennis A.","family":"Fried","sequence":"first","affiliation":[{"name":"War Related Illness and Injury Study Center VA\u2010New Jersey Healthcare System East Orange New Jersey"},{"name":"Department of Epidemiology Rutgers, The State University of New Jersey Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Sadeghi\u2010Nejad","sequence":"additional","affiliation":[{"name":"VA New Jersey Health Care System East Orange New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Gu","sequence":"additional","affiliation":[{"name":"MD Andersen Cancer Center, University of Texas Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"MD Andersen Cancer Center, University of Texas Houston Texas"},{"name":"College of Medicine Penn State University Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"He","sequence":"additional","affiliation":[{"name":"MD Andersen Cancer Center, University of Texas Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon H.","family":"Giordano","sequence":"additional","affiliation":[{"name":"MD Andersen Cancer Center, University of Texas Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Ram","family":"Pentakota","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Rutgers, The State University of New Jersey Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitaw","family":"Demissie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Rutgers, The State University of New Jersey Newark New Jersey"},{"name":"SUNY Downstate School of Public Health  Brooklyn New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Helmer","sequence":"additional","affiliation":[{"name":"War Related Illness and Injury Study Center VA\u2010New Jersey Healthcare System East Orange New Jersey"},{"name":"New Jersey Medical School, Rutgers, The State University of New Jersey Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Shen","sequence":"additional","affiliation":[{"name":"MD Andersen Cancer Center, University of Texas Houston Texas"},{"name":"College of Medicine Penn State University Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327481602300108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"e_1_2_8_5_1","unstructured":"The Numbers Count: Mental Disorders in America.National Institutes of Health.http:\/\/www.nimh.nih.gov\/health\/publications\/the-numbers-count-mental-disorders-in-america\/index.shtml#KesslerPrevalence. 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