{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:23:14Z","timestamp":1759616594432,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012615","name":"University of Texas Health Science Center at Houston","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Matrix metalloproteinases\u201020 (MMP20) expression is widely regarded as tooth specific, with expression limited to dental hard tissues. Recently, we reported MMP20 expression and interaction with dentin sialophosphoprotein (DSPP), a member of the Small Integrin Binding Ligand N\u2010linked Glycoproteins (SIBLINGs), in human oral squamous cell carcinoma (OSCC) and dysplastic oral premalignant lesions (OPLs), suggesting a role for MMP20\u2010DSPP interaction in oral carcinogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study aimed to survey the expression of MMP20 and its cognate DSPP partner in the breast, colon, prostate, thyroid, and cervical neoplasms. Using commercially available tissue microarrays (TMAs) and cell lines, we performed immunohistochemistry, immunofluorescence, proximity ligation assay, and western blot experiments to determine the expressions of MMP20 and DSPP in the breast, colon, prostate, thyroid, cervical neoplasms, and their normal counterparts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly high expression levels of MMP20 and DSPP were observed in the malignant breast, colon, prostate, thyroid, and cervical neoplasms compared with their benign and normal counterparts. Furthermore, MMP20 levels increased with advanced stages of colon and thyroid cancers. DSPP expression increased significantly with tumor stage in all cancers examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The co\u2010localization and potential MMP20\u2010DSPP interaction previously reported in oral cancers are present in other cancers. These results suggest MMP20\u2010DSPP pairing as a potential marker of disease activity in some epithelial cancers with diagnostic and prognostic implications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2117","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T09:29:55Z","timestamp":1554110995000},"page":"2167-2178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Survey of dentin sialophosphoprotein and its cognate matrix metalloproteinase\u201020 in human cancers"],"prefix":"10.1002","volume":"8","author":[{"given":"Jaya","family":"Aseervatham","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Biomedical Sciences University of Texas School of Dentistry at Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saxena","family":"Geetu","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Biomedical Sciences University of Texas School of Dentistry at Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles C.","family":"Anunobi","sequence":"additional","affiliation":[{"name":"Department of Anatomic and Molecular Pathology, College of Medicine University of Lagos Lagos Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Komal","family":"Koli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Biomedical Sciences University of Texas School of Dentistry at Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-0718","authenticated-orcid":false,"given":"Kalu U. 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