{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:36:47Z","timestamp":1767033407164,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["259332240 \/ RTG 2099"],"award-info":[{"award-number":["259332240 \/ RTG 2099"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne\u2010like skin reactions frequently occur in patients undergoing treatment with drugs inhibiting the epidermal growth factor receptor. Recently, the effects of vitamin K1 containing cream (Reconval K1) as prophylactic skin treatment in addition to doxycycline were explored in a double\u2010blind randomized phase II trial (EVITA) in patients with metastatic colorectal cancer receiving cetuximab. EVITA demonstrated a trend towards less severe skin rash in Reconval K1\u2010treated patients using the tripartite WoMo skin reaction grading score as a thorough tool for quantification of drug related skin reactions. This gender\u2010specific analysis of the EVITA trial evaluated the application of the WoMo score for assessment of epidermal growth factor receptor (EGFR)\u2010related skin toxicities according to treatment arm and gender. To show the robustness of results parametric and non\u2010parametric statistical analyses were conducted. All three parts of the WoMo score independently demonstrated the superiority of the treatment arm (Reconval K1) regarding a significant reduction in acneiform skin reactions in women. Men did not benefit from Reconval K1 cream at any time point in none of the WoMo score analyses. The treatment effect in women was confirmed by the use of skin rash categories based on the final WoMo overall score and mixed effect longitudinal multiple linear regression analysis. The WoMo score represents a sensitive tool for studies exploiting treatments against EGFR mediated acne\u2010like skin rash. Part C of the WoMo score seems to be sufficient for quantification of drug related skin toxicities in further studies. Standard WoMo skin reaction score values for future studies are provided.<\/jats:p>","DOI":"10.1002\/cam4.2132","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T14:49:15Z","timestamp":1560523755000},"page":"4169-4175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of EGFR inhibitor\u2010mediated acneiform skin toxicity within the double\u2010blind randomized EVITA trial: A thorough gender\u2010specific analysis using the WoMo score"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7936-8865","authenticated-orcid":false,"given":"Maria R.","family":"Gaiser","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center Mannheim, Ruprecht\u2010Karl University of Heidelberg Mannheim Germany"},{"name":"Skin Cancer Unit German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Lorenzen","sequence":"additional","affiliation":[{"name":"Medical Clinic III University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Merx","sequence":"additional","affiliation":[{"name":"Interdisciplinary Tumor Center Mannheim University Medical Center Mannheim, Ruprecht\u2010Karl University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-378X","authenticated-orcid":false,"given":"J\u00f6rg","family":"Trojan","sequence":"additional","affiliation":[{"name":"Medical Clinic I University Hospital Frankfurt Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janja","family":"Ocvirk","sequence":"additional","affiliation":[{"name":"Institute of Oncology Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Ettrich","sequence":"additional","affiliation":[{"name":"Medical Clinic I University Hospital Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah\u2010Eddin","family":"Al\u2010Batran","sequence":"additional","affiliation":[{"name":"Institute of Clinical Cancer Research (IKF) at Nordwest Hospital UCT\u2010University Cancer Center Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Schulz","sequence":"additional","affiliation":[{"name":"Oncological Practice Frechen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Homann","sequence":"additional","affiliation":[{"name":"Medical Clinic II Wolfsburg Wolfsburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Peter","family":"Feustel","sequence":"additional","affiliation":[{"name":"H\u00e4matologisch\u2010Onkologische Praxis Speyer Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schatz","sequence":"additional","affiliation":[{"name":"Medizinische Klinik II, ViDia Christliche Kliniken Karlsruhe Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Kripp","sequence":"additional","affiliation":[{"name":"Interdisciplinary Tumor Center Mannheim University Medical Center Mannheim, Ruprecht\u2010Karl University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Schulte","sequence":"additional","affiliation":[{"name":"Interdisciplinary Tumor Center Mannheim University Medical Center Mannheim, Ruprecht\u2010Karl University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Heeger","sequence":"additional","affiliation":[{"name":"Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soetkin","family":"Vlassak","sequence":"additional","affiliation":[{"name":"Neervelp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Koch","sequence":"additional","affiliation":[{"name":"BDS Koch Schwetzingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf\u2010Dieter","family":"Hofheinz","sequence":"additional","affiliation":[{"name":"Interdisciplinary Tumor Center Mannheim University Medical Center Mannheim, Ruprecht\u2010Karl University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.03.032"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.7828"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0051"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.14.251"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00715.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy451"},{"issue":"83","key":"e_1_2_7_9_1","first-page":"e1","article-title":"Patterns of sunscreen use on the face and other exposed skin among US adults","volume":"73","author":"Holman DM","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-015877"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(99)00390-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0545"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000181487"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.11.064"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.2132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.2132","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.2132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T02:07:14Z","timestamp":1694311634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.2132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,14]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/cam4.2132"],"URL":"https:\/\/doi.org\/10.1002\/cam4.2132","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2019,6,14]]},"assertion":[{"value":"2019-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}