{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:51:45Z","timestamp":1787068305794,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health Science and Technology Innovation Talents Project of Henan Province","award":["2109901"],"award-info":[{"award-number":["2109901"]}]},{"name":"Foundation and Frontier Technology Research Project in Henan Province","award":["142300410325"],"award-info":[{"award-number":["142300410325"]}]},{"name":"Key Science and Technology Research Project of Henan province","award":["162102310194"],"award-info":[{"award-number":["162102310194"]}]},{"name":"Medical Key Science and Technology Research Project of Henan province","award":["201503044"],"award-info":[{"award-number":["201503044"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Natural Killer T\u2013Cell Lymphoma (NKTCL) is a subtype of Non\u2010Hodgkin's Lymphoma, and its morbidity is ranked the first of T\u2010Cell Lymphoma. Hippo signaling pathway is involved in the pathogenesis of tumors. However, the role of Hippo signaling pathway in the oncogenesis of NKTCL still remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The expressions of mammalian sterile 20\u2010like kinase 1 (MST1) and Yes\u2010associated protein (YAP) were investigated by RT\u2010PCR and Western blotting. Cell viability was detected by MTT assays. Cell cycle and cell apoptosis were determined by flow cytometry. Cell proliferative capacity was detected by colony formation assay. Nude mice xenograft models were established and the tumor sections were analyzed by immunohistochemistry (IHC) staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The expression of MST1 was significantly down\u2010regulated in NKTCL tissues (n\u00a0=\u00a030) and cell lines, while the expression of YAP was significantly up\u2010regulated, and the phosphorylation of YAP was inhibited. Overexpression of MST1, knockdown of YAP, or verteporfin (VP) treatment could inhibit cell proliferation, and promote cell cycle arrest and apoptosis in NKTCL cells, while knockdown of MST1 and overexpression of YAP promoted cell proliferation. Additionally, Bcl\u20102\/Bax ratio and downstream effectors of Hippo signaling pathway (c\u2010myc, survivin, cyclinD1, CTGF, and TEAD) were significantly decreased when MST1 was overexpressed and YAP was knocked down or after VP treatment. Furthermore, our mice model demonstrated that activation of Hippo signal pathway suppressed the tumorigenesis of NKTCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The activation of Hippo signal pathway via overexpressing MST1 or down\u2010regulating YAP can inhibit the tumorigenesis of NKTCL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.2174","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:14:42Z","timestamp":1558656882000},"page":"3892-3904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Activated hippo signal pathway inhibits cell proliferation and promotes apoptosis in NK\/T cell lymphoma cells"],"prefix":"10.1002","volume":"8","author":[{"given":"Yu","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Oncology The 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