{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:34:23Z","timestamp":1777581263699,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pancreatic cancer (PC) is characterized by racial\/ethnic disparities and the debilitating muscle\u2010wasting condition, cancer cachexia. Florida ranks second in the number of PC deaths and has a large and understudied minority population. We examined the primary hypothesis that PC incidence and mortality rates may be highest among Black Floridians and the secondary hypothesis that biological correlates of cancer cachexia may underlie disparities. PC incidence and mortality rates were estimated by race\/ethnicity, gender, and county using publicly available state\u2010wide cancer registry data that included approximately 2700 Black, 25\u00a0200 Non\u2010Hispanic White (NHW), and 3300 Hispanic\/Latino (H\/L) Floridians diagnosed between 2004 and 2014. Blacks within Florida experienced a significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) higher incidence (12.5\/100\u00a0000) and mortality (10.97\/100\u00a0000) compared to NHW (incidence\u00a0=\u00a011.2\/100\u00a0000; mortality\u00a0=\u00a010.3\/100\u00a0000) and H\/L (incidence\u00a0=\u00a09.6\/100\u00a0000; mortality\u00a0=\u00a08.7\/100\u00a0000), especially in rural counties. To investigate radiologic and blood\u2010based correlates of cachexia, we leveraged data from a subset of patients evaluated at two geographically distinct Florida Cancer Centers. In Blacks compared to NHW matched on stage, markers of PC\u2010induced cachexia were more frequent and included greater decreases in core musculature compared to corresponding healthy control patients (25.0% vs 10.1% lower), greater decreases in psoas musculature over time (10.5% vs 4.8% loss), lower baseline serum albumin levels (3.8 vs 4.0\u00a0gm\/dL), and higher platelet counts (332.8 vs 268.7\u00a0k\/UL). Together, these findings suggest for the first time that PC and cachexia may affect Blacks disproportionately. Given its nearly universal contribution to illness and PC\u2010related deaths, the early diagnosis and treatment of cachexia may represent an avenue to improve health equity, quality of life, and survival.<\/jats:p>","DOI":"10.1002\/cam4.2180","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T04:10:51Z","timestamp":1557461451000},"page":"3314-3324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Racial and ethnic disparities in a state\u2010wide registry of patients with pancreatic cancer and an exploratory investigation of cancer cachexia as a contributor to observed inequities"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4726-9264","authenticated-orcid":false,"given":"Jennifer B.","family":"Permuth","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology Moffitt Cancer Center Tampa Florida"},{"name":"Department of 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