{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:39:30Z","timestamp":1761863970963,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aim<\/jats:title><jats:p>There is no standard salvage chemotherapy for metastatic periampullary adenocarcinoma and duodenal adenocarcinoma and the prognosis of those who fail oxaliplatin, irinotecan, and 5FU is dismal. We examined nanoparticle albumin\u2010bound paclitaxel (nab\u2010paclitaxel) as salvage therapy for these two malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who failed oxaliplatin, irinotecan, and 5FU and whose archival tumors stained immunohistochemical (IHC) tumor positive for CK7 or MUC1 received nab\u2010paclitaxel and gemcitabine therapy with or without cisplatin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three patients, 2 with metastatic ampullary adenocarcinoma and 1 with duodenal adenocarcinoma with positive IHC staining for CK7 or MUC1 who failed 2 lines of chemotherapy with oxaliplatin, irinotecan, and 5FU received nab\u2010paclitaxel and gemcitabine with or without cisplatin. All achieved excellent tumor response on CT scans with marked falls in tumor markers CA19\u20109 and CEA as well as \u22651\u00a0year of progression\u2010free survival. All 3 have continued to survive 2\u20103\u00a0years since diagnosed with stage 4 metastatic adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nab\u2010paclitaxel plus gemcitabine with or without cisplatin should be investigated as a standard\u2010of\u2010care chemotherapy regimen for patients with ampullary adenocarcinoma and duodenal adenocarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2181","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T04:10:14Z","timestamp":1558152614000},"page":"3464-3470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Durable response for ampullary and duodenal adenocarcinoma with a nab\u2010paclitaxel plus gemcitabine\u00a0\u00b1\u00a0cisplatin combination"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-311X","authenticated-orcid":false,"given":"Putao","family":"Cen","sequence":"first","affiliation":[{"name":"University of Texas McGovern Medical School at Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis J.","family":"Wray","sequence":"additional","affiliation":[{"name":"University of Texas McGovern Medical School at Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Texas McGovern Medical School at Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirav C.","family":"Thosani","sequence":"additional","affiliation":[{"name":"University of Texas McGovern Medical School at Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian Cuong","family":"Dinh","sequence":"additional","affiliation":[{"name":"Memorial Hermann\u2010Texas Medical Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneliese","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"University of Texas McGovern Medical School at Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Mohlere","sequence":"additional","affiliation":[{"name":"University of Texas McGovern Medical School at Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Steven","family":"Bynon","sequence":"additional","affiliation":[{"name":"University of Texas McGovern Medical School at Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21374"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908721"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.7145"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30445"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2603-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0396-x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.8868"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-007-0444-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304369"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443304"}],"container-title":["Cancer 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