{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:32:20Z","timestamp":1773448340042,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine potential predictors of long\u2010term survival in a large set of Hispanic (Mexican) patients with chronic myeloid leukemia (CML) treated with imatinib. We conducted an analysis with data from 411 patients with CML treated at the National Cancer Institute \u2013 Mexico, between January 2000 and December 2016. We found a median age at diagnosis of 40\u00a0years (range: 18\u201084\u00a0years). The survival rate at 150\u00a0months was 82.02%, and we found that phase at diagnosis (<jats:italic>\u03b2<\/jats:italic>: 0.447, 95% Confidence Interval [95% CI]: 0.088, 0.806; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015), prognostic scales (Sokal [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.021] and Hasford [<jats:italic>\u03b2<\/jats:italic>: 0.369, 95% CI: 0.049, 0.688; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.024]) and hematological response at 3\u00a0months (<jats:italic>\u03b2<\/jats:italic>: 0.717, 95% CI: 0.443, 0.991; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), but not molecular response (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.834 for 6\u00a0months, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.927 for 12\u00a0months, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.250 for 18\u00a0months), were independently associated with overall survival. Survival analysis in subsets, according to the initial phase (chronic, accelerated and blastic phase) did not show any effect according to prognostic scales (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Mexican patients with CML have repeatedly been diagnosed at earlier ages. Prognostic factors in CML may differ according to the ethnic or geographical context. We found that phase at diagnosis, prognostic scale and hematological response at 3\u00a0months were independent predictors of survival.<\/jats:p>","DOI":"10.1002\/cam4.2201","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T02:41:00Z","timestamp":1556851260000},"page":"2942-2949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic factors for overall survival in patients with chronic myeloid leukemia treated with imatinib at the National Cancer Institute \u2013 Mexico, from 2000 to 2016"],"prefix":"10.1002","volume":"8","author":[{"given":"Jimena","family":"Ylescas\u2010Soria","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica en C\u00e1ncer Instituto Nacional de Cancerolog\u00eda \u2013 Instituto de Investigaciones Biom\u00e9dicas Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Mexico City Mexico"},{"name":"Support and Research Promotion Program (AFINES), Faculty of Mefdicine Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo H.","family":"de la Torre\u2010Lujan","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Institute Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica en C\u00e1ncer Instituto Nacional de Cancerolog\u00eda \u2013 Instituto de Investigaciones Biom\u00e9dicas Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Miranda","sequence":"additional","affiliation":[{"name":"Support and Research Promotion Program (AFINES), Faculty of Mefdicine Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Grimaldo","sequence":"additional","affiliation":[{"name":"Department of Hematology Instituto Nacional de Cardiolog\u00eda \"Ignacio Ch\u00e1vez\" Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Rivas","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Institute Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Cervera","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica en C\u00e1ncer Instituto Nacional de Cancerolog\u00eda \u2013 Instituto de Investigaciones Biom\u00e9dicas Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abelardo","family":"Meneses\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica en C\u00e1ncer Instituto Nacional de Cancerolog\u00eda \u2013 Instituto de Investigaciones Biom\u00e9dicas Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fidias E.","family":"Leon-Sarmiento","sequence":"additional","affiliation":[{"name":"Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Mediciencias Research Group Unicolciencias\/Universidad Nacional Bogota 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Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-010-0016-z"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-015-0143-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2314-2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.17.7415"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23691"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25273"},{"key":"e_1_2_5_8_1","first-page":"44","article-title":"The age and sex frequencies of patients with leukemia seen in two reference centers in the metropolitan area of Mexico City","volume":"153","author":"Santoyo\u2010S\u00e1nchez A","year":"2017","journal-title":"Gac Med 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