{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:31:55Z","timestamp":1790627515463,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/aim<\/jats:title><jats:p>We assessed suitable factors indicating newly developed lenvatinib (LEN) treatment for unresectable hepatocellular carcinoma (u\u2010HCC) by investigating real\u2010world clinical features of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/methods<\/jats:title><jats:p>One hundred fifty two u\u2010HCC patients, who receive LEN treatment from March to December 2018, were enrolled. (Child\u2010Pugh score [CPS] 5\/6\/7\/8\u00a0=\u00a076\/61\/13\/2, modified albumin\u2010bilirubin grade [mALBI] 1\/2a\/2b\/3\u00a0=\u00a053\/35\/60\/4). Clinical features were evaluated retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall\u2010response rate (ORR)\/disease control rate (DCR) at 1\u00a0month after starting LEN were 38.7%\/86.0%, respectively. Estimated median time to progression (TTP) was 7.0\u00a0months, while median survival time was not reached within the observation period. CPS (\u22657) and past history of tyrosine\u2010kinase inhibitor (TKI) were not significant prognostic factors. mALBI \u22652b was an only significant prognostic factor (HR 4.632, 95%CI 1.649\u201013.02, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) in Cox\u2010hazard multivariate analysis. In patients with Child\u2010Pugh A, c\u2010index\/Akaike's information criterion (AIC) of prognostic predictive value of mALBI were superior to CPS (0.682\/135.6 vs 0.652\/138.7), while those of stopping LEN also showed that mALBI was better (0.575\/447.3 vs 0.562\/447.8). Additional analysis of patients with good mALBI (1\/2a) revealed that time to stopping LEN was significantly shorter in those with the adverse event (AE) of appetite loss (any grade) than those without (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and body mass index (BMI) was also lower in patients with that AE (20.3\u00a0\u00b1\u00a03.0 vs 23.6\u00a0\u00b1\u00a04.0kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), while patients with a hand\u2010foot skin reaction (any grade) showed good ORR\/DCR (59.1%\/86.4%) and longer TTP as compared to patients without (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Good hepatic function (mALBI 1\/2a) is the best indication for LEN, while potential appetite loss in association with low BMI should be kept in mind in such cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2241","type":"journal-article","created":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T04:17:11Z","timestamp":1558757831000},"page":"3719-3728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Prognostic factor of lenvatinib for unresectable hepatocellular carcinoma in real\u2010world conditions\u2014Multicenter analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-0480","authenticated-orcid":false,"given":"Atsushi","family":"Hiraoka","sequence":"first","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kumada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital Gifu 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Takaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Okayama City Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Kariyama","sequence":"additional","affiliation":[{"name":"Department of Hepatology Kagawa Prefectural Central Hospital Takamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ei","family":"Itobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asahi General Hospital Asahi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Tajiri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyama University Hospital Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritomo","family":"Shimada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Otakanomori Hospital Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokushima Prefectural Central Hospital Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Ochi","sequence":"additional","affiliation":[{"name":"Hepato\u2010biliary Center Matsuyama Red Cross Hospital Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Nouso","sequence":"additional","affiliation":[{"name":"Department of Hepatology Kagawa Prefectural Central Hospital Takamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Okayama City Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Okayama City Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Itokawa","sequence":"additional","affiliation":[{"name":"Center of Gastroenterology Teine Keijinkai Hospital Sapporo 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