{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:05:50Z","timestamp":1791216350730,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Most patients with gastric mucosa\u2010associated lymphoid tissue (MALT) lymphoma are infected with <jats:italic>Helicobacter pylori<\/jats:italic>, and eradication therapy is the first\u2010line treatment for localized disease with <jats:italic>H pylori<\/jats:italic> infection. However, there were several reports showing effectiveness of eradication therapy in even <jats:italic>H pylori<\/jats:italic> negative cases. Gastric MALT lymphomas are endoscopically classified into three common types: superficial, ulcerative, and elevated types. For the past 20\u00a0years, we have encountered 200 cases of localized gastric MALT lymphoma. Among them, only 4 cases (2%) showed similar macroscopic findings to those of nodular gastritis (gastric MALT lymphoma with nodular gastritis\u2010like appearance; M\u2010NGA). Here, we compared clinicopathological characteristics and prevalence of non\u2010<jats:italic>H pylori Helicobacter<\/jats:italic> (NHPH) infection between M\u2010NGA and other common types of gastric MALT lymphoma. To examine the prevalence of NHPH infection, DNA was extracted from formalin\u2010fixed paraffin\u2010embedded biopsy tissues from four cases of M\u2010NGA, 20 cases of common endoscopic types of gastric MALT lymphoma, and 10 cases of nodular gastritis. We used a highly sensitive polymerase chain reaction assay to detect the presence of five species of NHPH (<jats:italic>Helicobacter suis<\/jats:italic>, <jats:italic>H felis<\/jats:italic>, <jats:italic>H bizzozeronii<\/jats:italic>, <jats:italic>H salomonis<\/jats:italic>, and <jats:italic>H heilmannii<\/jats:italic>). <jats:italic>H suis<\/jats:italic> infection was detected in 4, 2, and 0 of the 4, 20, and 10 cases of M\u2010NGA, other types of gastric MALT lymphoma, and nodular gastritis, respectively. Other NHPH species were not detected in any cases. Complete response rate by eradication therapy was 4\/4 in M\u2010NGA cases. Therefore, nodular gastritis\u2010like MALT lymphoma, which shows a very rare phenotype, is closely associated with NHPH infection, and eradication therapy may be the first\u2010choice treatment.<\/jats:p>","DOI":"10.1002\/cam4.2314","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T09:40:26Z","timestamp":1560850826000},"page":"4370-4379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["<i>Helicobacter suis<\/i> infection is associated with nodular gastritis\u2010like appearance of gastric mucosa\u2010associated lymphoid tissue lymphoma"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-0641","authenticated-orcid":false,"given":"Hidehiko","family":"Takigawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Health and Science Prefectural University of Hiroshima Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikatsu","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yuge","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-1541","authenticated-orcid":false,"given":"Yuji","family":"Urabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-5414","authenticated-orcid":false,"given":"Kazuhiro","family":"Sentani","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiji","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Matsuonaika Hospital Mihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Matsuonaika Hospital Mihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Kitadai","sequence":"additional","affiliation":[{"name":"Department of Health and Science Prefectural University of Hiroshima Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-5-118"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2009.00535.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00041-08"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.3.634-637.1998"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8698198"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.2.137"},{"key":"e_1_2_8_8_1","first-page":"1149","article-title":"Helicobacter heilmannii\u2010like spiral bacteria in gastric mucosal biopsies. 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