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Although the exact mechanisms of GC are complex and poorly understood, gastric carcinogenesis is a good model to investigate how inflammation and infection collaboratively promote tumorigenesis. Yes\u2010associated protein 1 (YAP1) is the key effector of the Hippo pathway, which is silenced in most human cancers. Herein, we verified the tumor\u2010promoting effect of YAP1 in vitro, in vivo, and in human specimens. We revealed that YAP1 displays nuclear translocation and works with TEAD to activate transcription of the crucial inflammatory cytokine IL\u20101\u03b2 in gastric cells infected with <jats:italic>Hp<\/jats:italic>. As IL\u20101\u00df accounts for inflammation\u2010associated tumorigenesis, this process can lead to gastric carcinogenesis. Thus, in addition to activating proliferation genes, YAP1 also plays a major role in inflammation amplification by activating inflammatory cytokine genes. Excitingly, our research demonstrates that transfection of mutant plasmid YAP\u20105SA\/S94A or addition of the drug verteporfin, both of which are thought to disrupt the YAP1\u2010TEAD interaction, can arrest the carcinogenesis process. These findings can provide new approaches to GC treatment.<\/jats:p>","DOI":"10.1002\/cam4.2318","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T14:12:56Z","timestamp":1559225576000},"page":"3965-3980","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["<i>Helicobacter pylori<\/i>\u2010induced YAP1 nuclear translocation promotes gastric carcinogenesis by enhancing IL\u20101\u03b2 expression"],"prefix":"10.1002","volume":"8","author":[{"given":"Yujiao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Microbiology\/Key Laboratory for Experimental Teratology of Chinese Ministry of Education, School of Medicine Shandong University Jinan P. R. 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