{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:41:42Z","timestamp":1775576502243,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To define the clinical characteristics and prognostic value of pre\u2010retreatment plasma Epstein\u2010Barr virus (EBV) DNA, we investigated EBV status in locoregional recurrent nasopharyngeal carcinoma (lrNPC) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between April 2008 and August 2016, the data of patients with nonmetastatic lrNPC were retrospectively reviewed. The survival indexes of patients between different pre\u2010retreatment EBV status groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 401 patients with nonmetastatic lrNPC were enrolled, and 197 (49.1%) patients had detectable pre\u2010retreatment plasma EBV DNA. Treatment included radiotherapy alone (n\u00a0=\u00a037 patients), surgery alone (n\u00a0=\u00a0105), radiotherapy (n\u00a0=\u00a0208), surgery combined with radiotherapy (n\u00a0=\u00a020), chemotherapy and targeted therapy (n\u00a0=\u00a031). Median follow\u2010up was 32 months. The 3\u2010year locoregional relapse\u2010free survival (LRRFS), distant metastasis\u2010free survival (DMFS), and overall survival (OS) rates for the entire cohort were 64.8%, 89.4%, and 58.8%, respectively. The estimated 3\u2010year LRRFS, DMFS, and OS rates for the pre EBV\u2010positive group vs the pre EBV\u2010negative group were 54.2% vs 75.0% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), 86.6% vs 91.9% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05), 51.6% vs 65.9% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), respectively. Among patients in the clinical stage rI\/II, there were 17 patients in the radiotherapy alone group and 49 patients in the surgery alone group. And there was no significant difference in overall survival between radiotherapy and surgery, even among the different pre\u2010EBV statuses (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). In terms of long\u2010term toxic and side effects, the incidence of radioactive temporal lobe injury in the radiotherapy group was higher than that in the surgery group (35.3% vs 8.2%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and no statistically significant difference was found in other long\u2010term toxic and side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The positive rate of pre\u2010retreatment plasma EBV DNA in lrNPC is lower than primary NPC. The prognosis of EBV DNA negative group is better than positive group. For locally early\u2010stage lrNPC, regardless of EBV DNA status, radiotherapy and surgery are available options and both can achieve better long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2339","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T13:09:10Z","timestamp":1562159350000},"page":"4633-4643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical characteristics and prognostic value of pre\u2010retreatment plasma epstein\u2010barr virus DNA in locoregional recurrent nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2430-6517","authenticated-orcid":false,"given":"Ming\u2010Zhu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center Guangzhou Guangdong Province People's Republic of China"},{"name":"State Key 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