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Although intraocular metastasis (IOM) occurs at a later stage than metastasis to other organs, it often adversely affects the quality of life and suggests a poor prognosis. In this study, we selected 1608 patients with lung cancer who had metastasis to at least one site and explored clinical differences between those with IOM and non\u2010IOM (NIOM). An independent <jats:italic>t<\/jats:italic> test and chi\u2010squared test were used to analyze the clinical features of the patients. The statistically significant parameters were analyzed by binary logistic regression to determine the risk factors for IOM. A receiver operating characteristic curve was constructed to assess their diagnostic value in IOM. The results showed that no significant differences were noted in age, gender, and pathological type between the IOM and NIOM groups. However, the IOM group had higher levels of alpha\u2010fetoprotein, carcinoembryonic antigen, cancer antigen (CA)\u2010125, CA\u2010153, cytokeratin fragment 19 (CYFRA 21\u20101), and total prostate\u2010specific antigen, compared with the NIOM group. Binary logistic regression indicated that CA\u2010153 and CYFRA 21\u20101 were risk factors for IOM in patients with MLC (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Area under the curve of CA\u2010153, CYFRA 21\u20101 and their combination were 0.791, 0.860, and 0.872 respectively. The cutoff values for CA\u2010153 and CYFRA 21\u20101 were 22.2\u00a0U\/mL and 6.785\u00a0ng\/mL. In conclusion, both CA\u2010153 and CYFRA 21\u20101 were independent risk factors for IOM in patients with metastatic lung cancer (MLC), whereas the combination of CA\u2010153 and CYFRA 21\u20101 assessment yields the most value in the detection of IOM in patients with MLC.<\/jats:p>","DOI":"10.1002\/cam4.2354","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T08:09:26Z","timestamp":1561018166000},"page":"1279-1286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic value of CA\u2010153 and CYFRA 21\u20101 in predicting intraocular metastasis in patients with metastatic lung cancer"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-1674","authenticated-orcid":false,"given":"Qi","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan\u2010Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The First Affiliated Hospital of Nanchang University Nanchang Jiangxi People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Wen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Qing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Lan","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The First Affiliated Hospital of Nanchang University Nanchang Jiangxi People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People\u2019s Republic of 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