{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:37:37Z","timestamp":1772998657069,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"SIRIC BRIO Bordeaux"},{"name":"Canc\u00e9rop\u00f4le GSO"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Natural Killer (NK) cells are innate lymphoid cells that can be cytotoxic toward a large panel of solid tumors and hematological malignancies including chronic myeloid leukemia (CML). Such a cytotoxicity depends on various receptors. Killer immunoglobulin\u2010like receptors (KIR) belong to these receptors and are involved in maturation process, then in the activation abilities of NK cells. Methods: We investigated the prognostic impact of the\n                      <jats:italic>KIR2DL5B<\/jats:italic>\n                      genotype in 240 CML patients included in two clinical trials investigating tyrosine kinase inhibitors (TKI) discontinuation: STIM and STIM2. Results: After adjustment for standard risk factors in CML, we found that the inhibitory receptor\n                      <jats:italic>KIR2DL5B\u2010<\/jats:italic>\n                      positive genotype was independently related to a delayed second deep molecular remission (HR 0.54, 95% CI [0.32\u20100.91],\n                      <jats:italic>P\u00a0=\u00a0<\/jats:italic>\n                      0.02) after TKI rechallenge but not to time to first deep molecular remission or treatment\u2010free remission rates. Conclusion: These results suggest that\n                      <jats:italic>KIR2DL5B<\/jats:italic>\n                      could carry a role in lymphocyte\u2010mediated control of leukemic residual disease control in patient with CML relapse.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.2371","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T05:39:46Z","timestamp":1562650786000},"page":"4976-4985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Killer immunoglobulin\u2010like receptor genotypes and chronic myeloid leukemia outcomes after imatinib cessation for treatment\u2010free remission"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-3548","authenticated-orcid":false,"given":"Pierre\u2010Yves","family":"Dumas","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire CHU Bordeaux F-33000 Bordeaux France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale INSERM U1035 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"B\u00e9rard","sequence":"additional","affiliation":[{"name":"Service d'Epid\u00e9miologie Centre Hospitalier Universitaire de Toulouse Toulouse France"},{"name":"UMR 1027 INSERM\u2010Universit\u00e9 de Toulouse III Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Br\u00e9al","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire CHU Bordeaux F-33000 Bordeaux France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale INSERM U1035 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Dulucq","sequence":"additional","affiliation":[{"name":"Laboratoire 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de la Recherche M\u00e9dicale INSERM U1035 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Max","family":"Pasquet","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale INSERM U1035 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Turcq","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale INSERM U1218 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Bidet","sequence":"additional","affiliation":[{"name":"Laboratoire d'H\u00e9matologie CHU Bordeaux F-33000 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Milpied","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire CHU Bordeaux F-33000 Bordeaux 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