{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:32:27Z","timestamp":1790839947786,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T00:00:00Z","timestamp":1399420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>\n \n The prognostic accuracy of the\n CURB<\/jats:styled-content>\n \u201065 criteria and pneumonia severity index (\n PSI<\/jats:styled-content>\n ) in immunocompromised cancer patients with pneumonia is unknown. We sought to determine whether\n CURB<\/jats:styled-content>\n \u201065 and\n PSI<\/jats:styled-content>\n predict 28\u2010day mortality in cancer patients with pneumonia, and identify other factors that predispose cancer patients with pneumonia to a high mortality risk. We assessed sensitivities, specificities, predictive values, and areas under the receiver operating curve area under the curve (\n AUC<\/jats:styled-content>\n ) of the\n CURB<\/jats:styled-content>\n \u201065 and\n PSI<\/jats:styled-content>\n in predicting the 28\u2010day mortality of cancer patients presenting to our institution's emergency department with pneumonia. We used the DeLong and Clarke\u2013Pearson approach to determine whether the addition of other risk factors improved the scales' performances. The overall and pneumonia\u2010related 28\u2010day mortality rates were 20.2% (\n n<\/jats:italic>\n \u00a0=\u00a044) and 17.4% (\n n<\/jats:italic>\n \u00a0=\u00a038), respectively. In predicting 28\u2010day mortality, the\n CURB<\/jats:styled-content>\n \u201065 score had sensitivity of 45% and specificity of 81%, and the\n PSI<\/jats:styled-content>\n score had sensitivity of 82% and specificity of 34%. The\n CURB<\/jats:styled-content>\n \u201065 and\n PSI<\/jats:styled-content>\n discriminated poorly between fatal and nonfatal pneumonia cases (\n AUC<\/jats:styled-content>\n s, 0.664 and 0.658, respectively; 95% confidence interval [\n CI<\/jats:styled-content>\n ], 0.57\u20130.75 for each). The addition of radiation therapy (\n RT<\/jats:styled-content>\n ) within 4\u00a0weeks and stem cell transplant (\n SCT<\/jats:styled-content>\n ) significantly improved the\n AUC<\/jats:styled-content>\n s of the\n CURB<\/jats:styled-content>\n \u201065 (0.75; 95%\n CI<\/jats:styled-content>\n , 0.67\u20130.83) and\n PSI<\/jats:styled-content>\n (0.73; 95%\n CI<\/jats:styled-content>\n , 0.65\u20100.82). Inadequate performances of\n CURB<\/jats:styled-content>\n \u201065 and\n PSI<\/jats:styled-content>\n demonstrate that a tool for predicting pneumonia\u2010related mortality in cancer patients and other immunocompromised populations is needed. Pneumonia patients who have undergone recent\n RT<\/jats:styled-content>\n or (\n SCT<\/jats:styled-content>\n ) are at a high risk of dying from pneumonia and require special consideration when assessing pneumonia\u2010related mortality risk.\n <\/jats:p>","DOI":"10.1002\/cam4.240","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T02:18:48Z","timestamp":1399429128000},"page":"962-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Predicting pneumonia mortality using CURB\u201065, PSI, and patient characteristics in patients presenting to the emergency department of a comprehensive cancer center"],"prefix":"10.1002","volume":"3","author":[{"given":"Carmen","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Division of Internal Medicine UT MD Anderson Cancer Center 1515 Holcombe Blvd. Houston 77030 Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tami","family":"Johnson","sequence":"additional","affiliation":[{"name":"Pharmacy Clinical Programs UT MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Rolston","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases UT MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Merriman","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine UT MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Warneke","sequence":"additional","affiliation":[{"name":"Department of Biostatistics UT MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine UT MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,7]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Murphy S. L. J.Xu andK. D.Kochanek.2012.National Vital Statistics Reports Deaths: Preliminary Data for 2010.U.S. Department of Health and Human Services; January 11 2012."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1605"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.06.019"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/511159"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcr088"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.5.377"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701233360402"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-644ST"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9979"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2010.107235"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000050454.01978.3B"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_6_15_1","first-page":"1550","article-title":"The pneumonia severity index and the CRB\u201065 in cancer patients with community\u2010acquired pneumonia","volume":"13","author":"Aliberti S.","year":"2009","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis970"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2006\/195464"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00187811"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/526355"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6.3854"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940501)73:9<2296::AID-CNCR2820730910>3.0.CO;2-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00167707"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200508-097JS"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.240","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.240","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.240","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:30:10Z","timestamp":1695544210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,7]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1002\/cam4.240"],"URL":"https:\/\/doi.org\/10.1002\/cam4.240","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,7]]},"assertion":[{"value":"2013-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}