{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:59:54Z","timestamp":1790049594006,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH 1R03CA189\u2010462\u201001"],"award-info":[{"award-number":["NIH 1R03CA189\u2010462\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA142746"],"award-info":[{"award-number":["R01CA142746"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA233360"],"award-info":[{"award-number":["U01CA233360"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201015\u20101\u20100089"],"award-info":[{"award-number":["W81XWH\u201015\u20101\u20100089"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201016\u20101\u20100687"],"award-info":[{"award-number":["W81XWH\u201016\u20101\u20100687"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005292","name":"Brigham and Women's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006800","name":"Honorable Tina Brozman Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003135","name":"Minnesota Ovarian Cancer Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001282","name":"Ovarian Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>MicroRNAs have recently emerged as promising circulating biomarkers in diverse cancer types, including ovarian cancer. We utilized conditional, doxycycline\u2010induced fallopian tube (FT)\u2010derived cancer models to identify changes in miRNA expression in tumors and plasma, and further validated the murine findings in high\u2010grade ovarian cancer patient samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 566 biologically informative miRNAs in doxycycline\u2010induced FT and metastatic tumors as well as plasma samples derived from murine models bearing inactivation of <jats:italic>Brca<\/jats:italic>, <jats:italic>Tp53<\/jats:italic>, and <jats:italic>Pten<\/jats:italic> genes. We identified miRNAs that showed a consistent pattern of dysregulated expression and validated our results in human patient serum samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified six miRNAs that were significantly dysregulated in doxycycline\u2010induced FTs (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) and 130 miRNAs differentially regulated in metastases compared to normal fallopian tissues (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Furthermore, we validated miR\u201021a\u20105p, miR\u2010146a\u20105p, and miR\u2010126a\u20103p as dysregulated in both murine doxycycline\u2010induced FT and metastatic tumors, as well as in murine plasma and patient serum samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, we identified changes in miRNA expression that potentially accompany tumor development in murine models driven by commonly found genetic alterations in cancer patients. Further studies are required to test both the function of these miRNAs in driving the disease and their utility as potential biomarkers for diagnosis and\/or disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2416","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T13:38:55Z","timestamp":1568122735000},"page":"6709-6716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Defining fallopian\u00a0tube\u2010derived miRNA cancer signatures"],"prefix":"10.1002","volume":"8","author":[{"given":"Selam B.","family":"Dejene","sequence":"first","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-9448","authenticated-orcid":false,"given":"Anders 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