{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:32:37Z","timestamp":1771471957184,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["160411"],"award-info":[{"award-number":["160411"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study aim was to report survival and morbidity of all patients in Sweden with peritoneal mesothelioma treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as well as investigate whether the survival has increased on a population level since this treatment was nationalized 2011. Study data were collected from the Swedish HIPEC registry and the Swedish National Cancer Registry. All patients with peritoneal mesothelioma scheduled for CRS\/HIPEC treatment in Sweden January 2011 to March 2018 were retrieved from the Swedish HIPEC registry. Clinicopathological and survival data were collected. For population\u2010level analysis, all patients with diffuse malignant peritoneal mesothelioma (DMPM) were identified from the Swedish National Cancer Registry and data were retrieved from two separate 5\u2010year time periods: 1999\u20102003 and 2011\u20102015. Thirty\u2010two patients were accepted for CRS\/HIPEC. Four were open\/close cases. Two\u2010year survival rate was 84% or 59% when excluding borderline peritoneal mesotheliomas (n\u00a0=\u00a017). Median overall survival was not reached. Grade III\u2010IV Clavien\u2010Dindo events occurred in 22% with no mortality. From the national cancer registry, 102 DMPM cases were retrieved: 40 cases between 1999 and 2003, and 62 cases between 2011 and 2015 (corresponding to an increase from 0.9 to 1.24\/million\/year, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Six patients (10%) received CRS\/HIPEC in the second period. Median OS increased between periods from 7 to 15\u00a0months and 5\u2010year survival from 14% to 29% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). Peritoneal mesothelioma of both borderline and DMPM subtypes undergoing CRS\/HIPEC have good long\u2010term survival. The incidence of DMPM in Sweden has increased. Overall survival has increased alongside the introduction of CRS\/HIPEC, which may be a contributing factor.<\/jats:p>","DOI":"10.1002\/cam4.2436","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T14:59:21Z","timestamp":1567609161000},"page":"6468-6475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Peritoneal mesothelioma in Sweden: A population\u2010based study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-9450","authenticated-orcid":false,"given":"Peter H.","family":"Cashin","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Section of Surgery Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Jansson Palmer","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicin and Surgery Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Asplund","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University \u2010 Hospital\/\u00d6stra G\u00f6teborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Surgery Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingvar","family":"Syk","sequence":"additional","affiliation":[{"name":"Department of clinical science Lund University, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"174","article-title":"Continuous hyperthermic peritoneal 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