{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:05:36Z","timestamp":1783656336320,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16JC1400500"],"award-info":[{"award-number":["16JC1400500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Liver cancer is a commonly diagnosed malignancy in China. The etiologies of liver cancer are widely known, although studies on temporal trends in liver cancer caused by specific etiologies are rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on the incidence and mortality of liver cancer were retrieved from the Global Burden of Diseases Study 2017. The estimated annual percentage change (EAPC) was used to quantify temporal trends in the age\u2010standardized incidence rate (ASIR) and the age\u2010standardized mortality rate (ASMR) of liver cancer from 1990 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nationwide, the number of incident cases of liver cancer increased from 258\u00a0000 in 1990 to 515\u00a0900 in 2017. The ASIR decreased from 27.16 per 100\u00a0000 to 26.04 per 100\u00a0000 during this period, with an EAPC of \u22120.64 (95% confidence interval [CI] \u22120.84, \u22120.44). The number of deaths increased from 245\u00a0300 in 1990 to 418\u00a0200 in 2017, and the ASMR decreased from 26.72 to 21.30 (EAPC\u00a0=\u00a0\u22121.16, 95% CI \u22121.35, \u22120.97). The most pronounced decreases in the ASIR and ASMR were observed in liver cancer due to hepatitis B and in people aged 15\u201049\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Since the extensive efforts for prevention of hepatitis B virus infection, the incidence of liver cancer due to hepatitis B has significantly decreased. However, liver cancer due to hepatitis C, NASH, and other causes remains a major public health concern. Additional preventive strategies tailored to liver cancer are needed to further reduce its disease burden in China.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2477","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T08:13:44Z","timestamp":1565079224000},"page":"5787-5799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Changing trends in the disease burden of primary liver cancer caused by specific etiologies in China"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-6894","authenticated-orcid":false,"given":"Zhenqiu","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences Fudan University Shanghai China"},{"name":"Fudan University Taizhou Institute of Health Sciences Taizhou 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