{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:16:08Z","timestamp":1762604168108,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["B70489\u201001"],"award-info":[{"award-number":["B70489\u201001"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prognostic factors for single primary gliosarcoma (PGS) remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of our study was to examine patient, tumor, and treatment characteristics as potential predictors of survival using Surveillance, Epidemiology, and End Results (SEER) program data (1973\u20102013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patients of single PGS were selected based on the exclusion criteria from SEER. Kaplan\u2010Meier survival analysis, log\u2010rank test and Cox proportional hazards models were used to analyze all the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Single PGS has an apparent popularity for the temporal lobe (35.2%, hazard ratio [HR]\u00a0=\u00a00.440, 95%CI\u00a0=\u00a00.251\u20100.770) and frontal lobe (20.9%, HR\u00a0=\u00a00.408, 95%CI\u00a0=\u00a00.231\u20100.720) which could achieve a better survival rate than cerebrum (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.034). The mean age at diagnosis was 60.07\u00a0\u00b1\u00a014.161. The overall 6\u2010month, 1\u2010year, 2\u2010year, and 5\u2010year survival was 55.40%, 29.58%, 10.01%, and 2.73%. Age at diagnosis was proved to be a significant predictor of overall survival (OS) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). There is no significant difference in race, marital status, or grade. Patients' tumor size which is located in 41\u201060\u00a0mm (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.047, HR\u00a0=\u00a01.468, 95%CI\u00a0=\u00a01.004\u20102.147) and &gt;60\u00a0mm (<jats:italic>P<\/jats:italic>= .003, HR\u00a0=\u00a01.899, 95%CI\u00a0=\u00a01.244\u20102.901) showed a higher risk of death. Surgery played a critical role in OS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Radiation after surgery was another predictor of OS of PGS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Among all the radiation methods, combination of beam with implants or isotopes (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.000, HR\u00a0=\u00a00.491, 95%CI\u00a0=\u00a00.412\u20100.585) or radiation NOS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.027, HR\u00a0=\u00a00.362, 95%CI\u00a0=\u00a00.148\u20100.889) were more beneficial to patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicated that single PGS has a poor prognosis. Prognosis of single PGS would become poorer along with patients' age and tumor size (&gt;40\u00a0mm). Surgery intervention and radiation therapy were beneficial factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2503","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T06:40:12Z","timestamp":1567060812000},"page":"6233-6242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prognostic factors among single primary gliosarcoma cases: A study using Surveillance, Epidemiology, and End Results data from 1973\u20132013"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9588-3691","authenticated-orcid":false,"given":"Bin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Peking University Third Hospital Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Peking University Third Hospital Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Peking University Third Hospital Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Peking University Third Hospital Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"405","article-title":"Ueber Entstehung und Bauder Gehirnglioma","volume":"19","author":"Stroebe H","year":"1895","journal-title":"Beitr Pathol Anat Allg Pathol"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"633","article-title":"Sarcoma arising in glioblastoma of the brain","volume":"31","author":"Feigin IH","year":"1955","journal-title":"Am J Pathol"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1007\/s00401-007-0243-4"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.3171\/jns.1976.45.4.0398"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1007\/BF00334506"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1007\/s11060-009-9973-6"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1007\/s11060-012-1029-7"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.3109\/02688697.2011.570881"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1002\/1097-0142(19910501)67:9<2342::AID-CNCR2820670922>3.0.CO;2-B"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1215\/15228517-2008-076"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1016\/S0167-8140(01)00415-7"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1016\/j.currproblcancer.2012.03.011"},{"doi-asserted-by":"publisher","key":"e_1_2_9_14_1","DOI":"10.1227\/NEU.0000000000000619"},{"unstructured":"SEER\u2010Stat Software Version 8.3.5. 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