{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:32:57Z","timestamp":1793413977347,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea(NRF) grant funded by the Korea government","award":["NRF-2016R1A2B4007282"],"award-info":[{"award-number":["NRF-2016R1A2B4007282"]}]},{"name":"The Korean Association of Internal Medicine grant","award":["2016-144"],"award-info":[{"award-number":["2016-144"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ibrutinib is highly effective in patients with relapsed or refractory mantle cell lymphoma (MCL) in major clinical trials. Although there has been a dramatic improvement in survival outcomes in the salvage setting, nonresponders to ibrutinib have a bleak prognosis. Therefore, this retrospective study was conducted to identify the most appropriate therapeutic strategy and prognosis\u2010related factors to predict the response of patients with relapsed or refractory MCL to ibrutinib monotherapy. Thirty\u2010three consecutive refractory or relapsed MCL patients treated with ibrutinib were analyzed in this study. The median overall survival (OS) and progression\u2010free survival (PFS) after initiation of ibrutinib were 35.1\u00a0months and 27.4\u00a0months, respectively. Risk factor analysis showed that high risk according to the Mantle Cell Lymphoma International Prognostic Index (MIPI) and nonresponse to ibrutinib at the first three cycles were significantly associated with inferior OS. Poor PFS was associated with high\u2010risk biologic MIPI, prior bendamustine exposure, and nonresponse to ibrutinib during the first three cycles. After ibrutinib failure, primary nonresponders had poorer OS and PFS than inconsistent responders. The overall response rate for the first salvage therapy was only 33%, with a median TTP of 3.2\u00a0months. There was no effective therapeutic strategy except for allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). Although ibrutinib responders exhibited favorable survival outcomes, nonresponders had a dismal prognosis. To overcome these limitations, it may be necessary to modify therapeutic strategies, such as selecting inconsistent responders for earlier allo\u2010HSCT.<\/jats:p>","DOI":"10.1002\/cam4.2565","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T10:08:15Z","timestamp":1569578895000},"page":"6860-6870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Clinical outcomes for ibrutinib in relapsed or refractory mantle cell lymphoma in real\u2010world experience"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3362-8200","authenticated-orcid":false,"given":"Young\u2010Woo","family":"Jeon","sequence":"first","affiliation":[{"name":"Division of Lymphoma\u2010Myeloma Catholic Hematology Hospital Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"Institute for Translational Research and Molecular Imaging 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Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Je","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Lymphoma\u2010Myeloma Catholic Hematology Hospital Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Lymphoma\u2010Myeloma Catholic Hematology Hospital Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Ki","family":"Min","sequence":"additional","affiliation":[{"name":"Division of Lymphoma\u2010Myeloma Catholic Hematology Hospital Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul 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