{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:38:36Z","timestamp":1784371116841,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007747","name":"University of Utah","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010638","name":"Huntsman Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010638","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA42014"],"award-info":[{"award-number":["P30 CA42014"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["HHSN261201800016I"],"award-info":[{"award-number":["HHSN261201800016I"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are few reports of the association of other cancers with Ewing sarcoma in patients and their relatives. We use a resource combining statewide genealogy and cancer reporting to provide unbiased risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a combined genealogy of 2.3 million Utah individuals and the Utah Cancer Registry (UCR), relative risks (RRs) for cancers of other sites were estimated in 143 Ewing sarcoma patients using a Cox proportional hazards model with matched controls; however, risks in relatives were estimated using internal cohort\u2010specific cancer rates in first\u2010, second\u2010, and third\u2010degree relatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cancers of three sites (breast, brain, complex genotype\/karyotype sarcoma) were observed in excess in Ewing sarcoma patients. No Ewing sarcoma patients were identified among first\u2010, second\u2010, or third\u2010degree relatives of Ewing sarcoma patients. Significantly increased risk for brain, lung\/bronchus, female genital, and prostate cancer was observed in first\u2010degree relatives. Significantly increased risks were observed in second\u2010degree relatives for breast cancer, nonmelanoma eye cancer, malignant peripheral nerve sheath cancer, non\u2010Hodgkin lymphoma, and translocation sarcomas. Significantly increased risks for stomach cancer, prostate cancer, and acute lymphocytic leukemia were observed in third\u2010degree relatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This analysis of risk for cancer among Ewing sarcoma patients and their relatives indicates evidence for some increased cancer predisposition in this population which can be used to individualize consideration of potential treatment of patients and screening of patients and relatives.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2575","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T14:39:30Z","timestamp":1572532770000},"page":"7924-7930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Increased risk for other cancers in individuals with Ewing sarcoma and their relatives"],"prefix":"10.1002","volume":"8","author":[{"given":"Diana","family":"Abbott","sequence":"first","affiliation":[{"name":"Genetic Epidemiology Department of Internal Medicine University of Utah School of Medicine Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schuyler","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Farnham","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology Department of Internal Medicine University of Utah School of Medicine Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Young","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Yap","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah Salt Lake City UT USA"},{"name":"Department of Orthopedic Surgery University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Jones","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah Salt Lake City UT USA"},{"name":"Department of Radiology University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Lessnick","sequence":"additional","affiliation":[{"name":"Center for Childhood Cancer and Blood Diseases at Nationwide Children's Hospital Division of Pediatric Hematology\/Oncology\/Blood and Marrow Transplant The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Lor","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery UC Davis Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Schiffman","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah Salt Lake City UT USA"},{"name":"Division of Pediatric Hematology\/Oncology Department of Pediatrics University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2602-3668","authenticated-orcid":false,"given":"Lisa A.","family":"Cannon\u2010Albright","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology Department of Internal Medicine University of Utah School of Medicine Salt Lake City UT USA"},{"name":"Huntsman Cancer Institute University of Utah Salt Lake City UT USA"},{"name":"George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0294-146"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1200933"},{"key":"e_1_2_8_4_1","first-page":"1229","article-title":"A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1","volume":"10","author":"Jeon 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