{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:02:36Z","timestamp":1758398556285,"version":"3.40.5"},"reference-count":49,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of breast cancer has increased dramatically in China. We evaluated the clinical and epidemiologic factors associated with breast cancer, and its stage in a case\u2010control study of Northeast Chinese women. We also examined whether these factors were differentially distributed among molecular subtypes of breast cancer in a case\u2010only analysis. We identified 1118 breast cancer patients and 2284 healthy women from Cancer Hospital of Medical University between January 2014 and December 2017. Logistic regression models were used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). We found that postmenopausal women had a decreased risk of breast cancer (multivariate\u2010adjusted OR\u00a0=\u00a00.33, 95% CI:0.25\u20100.43), and tended to have breast cancer of human epidermal growth factor receptor 2 (HER2)\u2010overexpressing (multivariate\u2010adjusted OR\u00a0=\u00a02.99, 95% CI: 1.49\u20105.97) and triple\u2010negative (multivariate\u2010adjusted OR\u00a0=\u00a02.16, 95% CI: 1.02\u20104.56) subtypes, compared with the luminal B subtype. Women with history of abortion had an increased risk of breast cancer (multivariate\u2010adjusted OR\u00a0=\u00a04.70, 95% CI: 3.60\u20106.14). Women with high breast density and high Breast Imaging Reporting and Data System (BIRADS) scores of lesions tended to have breast cancer of advanced stage, but were not differentially distributed among its molecular subtypes. In conclusion, postmenopausal women had decreased risk of breast cancer, and tended to have nonluminal subtype, while women with history of abortion had increased risk of breast cancer. Women with high breast density and BIRADS scores of lesions tended to have advanced stage breast cancer. We provide evidence on the epidemiologic factors for breast cancer and its subtypes, which may help with breast cancer risk stratification.<\/jats:p>","DOI":"10.1002\/cam4.2589","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T12:03:17Z","timestamp":1571832197000},"page":"7431-7445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-0283","authenticated-orcid":false,"given":"Dong\u2010Man","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Liaoning Cancer Hospital &amp; Institute Cancer Hospital of China Medical University Shenyang P. R. China"},{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing) Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of pathology Liaoning Cancer Hospital &amp; Institute Cancer Hospital of China Medical University Shenyang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Liaoning Cancer Hospital &amp; Institute Cancer Hospital of China Medical University Shenyang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao\u2010Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical College Dalian Medical University Dalian P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Hong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Liaoning Cancer Hospital &amp; Institute Cancer Hospital of China Medical University Shenyang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing) Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70425-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4325-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2531-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600596"},{"issue":"49","key":"e_1_2_8_8_1","first-page":"703","article-title":"Breast cancer research in Asia: adopt or adapt Western knowledge?","volume":"2013","author":"Bhoo\u2010Pathy N","year":"1990","journal-title":"Eur J Cancer"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv107"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70567-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3947-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.04.024"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35021093"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4080-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq239"},{"key":"e_1_2_8_16_1","first-page":"134","volume-title":"ACR BI\u2010RADS Atlas, Breast Imaging Reporting and Data System","author":"Sickles E","year":"2013"},{"volume-title":"Radiology ACo: Breast Imaging Reporting and Data System (BI\u2010RADS)","year":"2004","key":"e_1_2_8_17_1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.6529"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27513"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp082"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20120217"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju078"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-018-0055-9"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2531-0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015714305420"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/303767a0"},{"key":"e_1_2_8_27_1","first-page":"7415","article-title":"Increased cell division as a cause of human cancer","volume":"50","author":"Preston\u2010Martin S","year":"1990","journal-title":"Can Res"},{"key":"e_1_2_8_28_1","first-page":"3744","article-title":"Plasma insulin\u2010like growth factor (IGF) I, IGF\u2010binding protein 3, and mammographic density","volume":"60","author":"Byrne C","year":"2000","journal-title":"Can Res"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003293"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2012"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-009-9308-7"},{"key":"e_1_2_8_32_1","first-page":"1053","article-title":"Hormonal factors and the risk of breast cancer according to estrogen\u2010 and progesterone\u2010receptor subgroup","volume":"12","author":"Cotterchio M","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.359"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8349185"},{"key":"e_1_2_8_35_1","first-page":"497","article-title":"Susceptibility of the mammary gland to carcinogenesis. 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