{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:16:29Z","timestamp":1770142589089,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["128608\u2010RSGI\u201015\u2010211\u201001\u2010CPHPS"],"award-info":[{"award-number":["128608\u2010RSGI\u201015\u2010211\u201001\u2010CPHPS"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005002","name":"California Department of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["HHSN261201000140C"],"award-info":[{"award-number":["HHSN261201000140C"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006034","name":"University of Southern California","doi-asserted-by":"publisher","award":["HHSN261201000034C"],"award-info":[{"award-number":["HHSN261201000034C"]}],"id":[{"id":"10.13039\/100006034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U58DP003862\u201001"],"award-info":[{"award-number":["U58DP003862\u201001"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Guidelines recommend bone\u2010modifying agents (BMAs) for all patients initiating treatment for myeloma. We examined adherence to this recommendation, and BMA effectiveness in the era of bortezomib\/lenalidomide\u2010based therapy among Medicare beneficiaries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the linked Surveillance, Epidemiology, and End Results\u2010Medicare registry, we selected beneficiaries receiving anti\u2010myeloma chemotherapy in 2007\u20102013. We matched BMA recipients (within 90\u00a0days of first chemotherapy) to nonrecipients using a propensity score, balancing patient\u2010, disease\u2010, and therapy\u2010related confounders. Cumulative incidence of skeletal\u2010related events (SREs) and overall survival (OS) was compared in proportional hazard models accounting for competing risks and immortal\u2010time bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 4611 patients with median age of 76\u00a0years, 51% received BMA. Bone\u2010modifying agents use remained steady over time (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.87) and was significantly less frequent for patients who were older, with comorbidities, without prior SRE, and those treated without bortezomib or lenalidomide. In a propensity score\u2010matched cohort, BMA recipients experienced a lower incidence of SRE (11.0% vs 14.6% at 3\u00a0years; subhazard ratio, 0.73; 95% CI, 0.60\u20100.89) and better OS (53.3% vs 47.8% at 3\u00a0years; hazard ratio, 0.86; 95% CI, 0.77\u20100.95). The results were consistent in the subgroup (76%) treated with bortezomib and\/or immunomodulatory drugs (IMiDs). The incidence of osteonecrosis of the jaw (ONJ) was 3.2% at 3\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this observational study, the observed benefits of early BMA administration among patients treated with contemporary anti\u2010myeloma regimens were similar to historical clinical trials. Frequent omission of BMA highlights a remediable deficiency in the quality of supportive care, and suggests that timely administration may be a useful indicator of quality care in myeloma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2591","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:02:34Z","timestamp":1569906154000},"page":"6945-6954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Use of bone\u2010modifying agents and clinical outcomes in older adults with multiple myeloma"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-6658","authenticated-orcid":false,"given":"Adam J.","family":"Olszewski","sequence":"first","affiliation":[{"name":"Alpert Medical School of Brown University Providence RI USA"},{"name":"Division of Hematology\u2010Oncology Lifespan Cancer Institute Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-8376","authenticated-orcid":false,"given":"Peter M.","family":"Barth","sequence":"additional","affiliation":[{"name":"Alpert Medical School of Brown University Providence RI USA"},{"name":"Division of Hematology\u2010Oncology Lifespan Cancer Institute Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-6863","authenticated-orcid":false,"given":"John L.","family":"Reagan","sequence":"additional","affiliation":[{"name":"Alpert Medical School of Brown University Providence RI USA"},{"name":"Division of Hematology\u2010Oncology Lifespan Cancer Institute Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602223340802"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23783"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62051-X"},{"key":"e_1_2_10_5_1","first-page":"CD003188","article-title":"Bisphosphonates in multiple myeloma: a network meta\u2010analysis","volume":"5","author":"Mhaskar R","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-392522"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.128439"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30072-X"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3211"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi235"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03824.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.7901"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.117176"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.6402"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14815"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25492"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30747"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-298760"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.77.8894"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200208001-00002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.2447"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1300-8"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.148858"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000122"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00256-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg074"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.2659"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5984"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533848"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.1269"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1864"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.18.00085"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31594-X"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.267"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.2.593"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0225"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70198-4"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19425"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.2591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.2591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.2591","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.2591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T15:01:45Z","timestamp":1710255705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.2591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":39,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/cam4.2591"],"URL":"https:\/\/doi.org\/10.1002\/cam4.2591","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,30]]},"assertion":[{"value":"2019-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}