{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:32:02Z","timestamp":1782732722673,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672765"],"award-info":[{"award-number":["81672765"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many studies have documented the abnormal concentrations of major\/trace elements in serum or malignant tissues of patients, but very few works systematically tested the concentrations of elements in tumor tissues in comparison with paired adjacent normal tissues from the same patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tumor and adjacent normal lung tissues were obtained from 93 patients with previously untreated NSCLC, and 43 patients whose tumor and paired normal lung tissues reached 200\u00a0mg or more were selected for measurement of the elements' concentrations using an inductively coupled plasma\u2010atomic emission spectrometer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the concentrations of the 52 elements varied from 0.4\u00a0ng\/g tissue (Lu, Pd, and Tm) to 1\u00a0658\u00a0000\u00a0ng\/g (Na), 1\u00a0951\u00a0000\u00a0ng\/g (P), and 2\u00a0495\u00a0000\u00a0ng\/g (K). Thirty eight of the 52 (73.1%) elements showed approximately equal concentrations in tumor and adjacent normal lung tissues of the patients. The concentrations of nine elements (K, P, Mg, Zn, Rb, Cu, Se, Cs, and Tl) in tumor samples were significantly higher than their paired normal lung tissues, and five elements (Na, Fe, Cr, Cd, and Ge) exhibited decreased concentrations in cancer samples compared to counterpart normal lung tissues. Low Fe in tumor samples was associated with smoking history, whereas low Cr was associated with histology (squamous cell carcinoma) of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that measurement of elements\u2019 concentrations in both cancer and paired normal tissues is important to get insights into the roles of these elements in carcinogenesis, and therapeutic approaches to normalize the elements are warranted to treat NSCLCs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2629","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T19:09:26Z","timestamp":1571857766000},"page":"7720-7727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Systematic analysis of concentrations of 52 elements in tumor and counterpart normal tissues of patients with non\u2010small cell lung cancer"],"prefix":"10.1002","volume":"8","author":[{"given":"Xin","family":"Cheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences and University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Chun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Third Affiliated Hospital of Kunming Medical University (Yunnan Tumor Hospital) Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences and 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