{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:55:36Z","timestamp":1784231736941,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2016YFC0905003"],"award-info":[{"award-number":["2016YFC0905003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Extranodal marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue (MALT lymphoma) in the oromaxillofacial head and neck region is rare, with limited data available. This retrospective study explored the clinical features, stage, treatment, and prognosis of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 105 patients with MALT lymphomas in the oromaxillofacial head and neck region were included in this retrospective analysis. SPSS 22.0 software package was used for data analysis and a two\u2010tailed <jats:italic>P<\/jats:italic> value of \u2264.05 was considered statistically significant. Primary endpoints of the study were the complete response (CR) rate, overall survival (OS), and progression\u2010free survival (PFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 52% of the patients had long\u2010term xerostomia, autoimmune diseases, or chronic parotitis and 81% had diseases involving the large salivary glands. Ann Arbor staging of the patients was as follows: stages I\/II, 73 patients and stages III\/IV, 32 patients. In the 97 patients followed up, CR rate after initial treatment was 80%. Tumor progression was observed in 12 patients and 14 patients died. There was a significant difference between the rate of CR in localized (87%) and disseminated (67%) lymphoma patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). The 5\u2010 and 10\u2010year PFS of the localized lymphoma patients were both 91%, whereas those of the disseminated lymphoma patients were 83% and 65%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). The 5\u2010year PFS rates of the chemotherapy and non\u2010chemotherapy groups in the disseminated lymphoma patients were 85% and 73% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Meanwhile, the 5\u2010year PFS rates of the rituximab and non\u2010rituximab groups in the disseminated lymphoma patients were 100% and 70% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). In multivariate analysis, MALT Lymphoma International Prognostic Index (MALT\u2010IPI) was an independent prognostic factor affecting OS, whereas Ann Arbor staging affected PFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that the outcome after initial treatment of MALT lymphomas in the oromaxillofacial head and neck region is satisfactory and that this disease progresses slowly. The CR rate and PFS of localized lymphoma patients are better than those of disseminated lymphoma patients. Systemic treatment (chemotherapy or rituximab) may improve PFS in disseminated disease patients. MALT\u2010IPI and Ann Arbor staging are independent prognostic factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2681","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T04:19:35Z","timestamp":1573877975000},"page":"194-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Extranodal marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue in the oromaxillofacial head and neck region: A retrospective analysis of 105 patients"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-4087","authenticated-orcid":false,"given":"Tian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of oromaxillofacial head and neck region Oncology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunteng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of oromaxillofacial head and neck region Oncology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houyu","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of oromaxillofacial head and neck region Oncology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Stomatology  Central Hospital of Xuzhou Xuzhou Clinical College of Xuzhou Medical University Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-8765","authenticated-orcid":false,"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of oromaxillofacial head and neck region Oncology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of oromaxillofacial head and neck region Oncology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"issue":"02","key":"e_1_2_9_5_1","first-page":"111","article-title":"Distribution pattern of lymphoma subtypes in China: a nationwide multicenter study of 10002 cases","volume":"11","author":"Li X","year":"2012","journal-title":"J Diagnos Concept Practice"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.12.1621"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.3.802.003k19_802_806"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1279"},{"issue":"2","key":"e_1_2_9_9_1","first-page":"499","article-title":"Clinical and histological aspects with therapeutic implications in head and neck lymphomas","volume":"56","author":"Tusaliu M","year":"2015","journal-title":"Rom J Morphol Embryol"},{"issue":"05","key":"e_1_2_9_10_1","first-page":"296","article-title":"A retrospective clinical study of 6539 cases of malignant oral_maxillofacial 10 tumors. 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