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We retrospectively analyzed 80 patients with pathologically confirmed MALT lymphoma from 2006 to 2018. The clinical characteristics, diagnosis, treatments, and prognoses of all the 80 patients were recorded. Patients were stratified into surgery and biopsy groups, respectively, to evaluate the role of surgery in the diagnosis and treatment of MALT lymphoma. The prognoses were compared between different clinical characteristics and treatments. Pathological diagnoses were confirmed by surgery, bronchoscopy, and percutaneous biopsy. Thirty patients were treated by surgery. While MALT lymphoma was only diagnosed by bronchofiberoscopy or bercutaneous biopsy in four of 18 patients in the surgery group who underwent the procedure. Six patients received adjuvant chemotherapy and one patient received involved\u2010field radiotherapy in surgery group. Thirty\u2010one patients were treated with chemotherapy alone, one patient was treated with radiotherapy, one patient received only symptomatic and supportive treatment, and waiting and watching without treatment were recommended in 17 patients in biopsy group. Eight patients died during follow\u2010up and the 5\u2010year survival rate was 87.1%. Tumor number, treatment, and age were prognostic factors for overall survival (OS), but age was the only independent prognostic factor according to multivariate analysis. While, tumor number was the only prognostic factor in the analysis about progression\u2010free survival (PFS). No significant difference was found in OS or PFS between patients treated with and without surgical resection. MALT lymphoma is an indolent disease with favorable treatment outcome. Tumor number is associated with PFS and age is the only significant prognostic factor for pulmonary MALT lymphoma patients because of its indolent nature, but surgery still plays an important role in the diagnosis and treatment of MALT lymphoma.<\/jats:p>","DOI":"10.1002\/cam4.2683","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T04:05:13Z","timestamp":1573013113000},"page":"7660-7668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Clinical characteristics, diagnosis, treatment, and prognostic factors of pulmonary mucosa\u2010associated lymphoid tissue\u2010derived lymphoma"],"prefix":"10.1002","volume":"8","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanzhi","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghe","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8745-9276","authenticated-orcid":false,"given":"Cheng","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongkui","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8868-4405","authenticated-orcid":false,"given":"Zongwu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4230-5120","authenticated-orcid":false,"given":"Di","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4853-1727","authenticated-orcid":false,"given":"Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000180"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01535-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1016468"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050609"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01701-2015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh102"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/109.5.600"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb01318.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603981"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12703"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9430-17"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00039309"},{"key":"e_1_2_7_15_1","unstructured":"CookJR IsaacsonPG ChottA et al.Extranodal marginal zone lymphoma of mucosa\u2010associated lymphoid tissue (MALT lymphoma). 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