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However, more direct body fat measures may more accurately determine the relationship between body fat distribution and breast cancer risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cox proportional hazards regression models were created to examine the associations of dual\u2010energy x\u2010ray absorptiometry (DXA) body fat measures (at baseline and during follow\u2010up) with breast cancer risk among 10\u00a0931 postmenopausal women from the Women's Health Initiative cohort. A total of 639 incident invasive breast cancer cases (including 484 estrogen receptor positive (ER+) cases) were ascertained after a median follow\u2010up of 15.0\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Excess whole body fat mass and trunk fat mass were positively associated with risk invasive breast cancer risk. These associations persisted even after additional adjustment for standard anthropometric measures. In time\u2010dependent analyses, we observed that both whole body fat mass and trunk fat mass, in the highest versus lowest category, were associated with a doubling of risk of invasive breast cancer overall (HR: 2.17; 95% CI: 1.54\u20103.05 and 2.20; 1.55\u20103.14, respectively) and of ER+ breast cancer (2.05; 1.37\u20103.05 and 2.03; 1.34\u20103.07, respectively). The remaining DXA measures were also positively associated with breast cancer risk in baseline and time\u2010dependent analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that DXA\u2010derived body fat measures are positively associated with breast cancer risk after adjustment for BMI and other conventional breast cancer risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.2690","type":"journal-article","created":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T04:41:52Z","timestamp":1577248912000},"page":"1581-1599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The association between DXA\u2010derived body fat measures and breast cancer risk among postmenopausal women in the Women's Health Initiative"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-2945","authenticated-orcid":false,"given":"Rhonda S.","family":"Arthur","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Kamensky","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan T.","family":"Chlebowski","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-6761","authenticated-orcid":false,"given":"Michael","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Oncology Karmanos Cancer Institute Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhua","family":"Luo","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Biostatistics School of Public Health Indiana University Bloomington Bloomington IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Department of Family Medicine and Public Health University of California San Diego School of Medicine La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian L.","family":"Neuhouser","sequence":"additional","affiliation":[{"name":"Cancer Prevention Program Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Banack","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health School of Public Health and Health Professions University at Buffalo The State University of New York Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Y. 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