{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:06:23Z","timestamp":1790665583899,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011072","name":"Center for AIDS Research, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA019014"],"award-info":[{"award-number":["CA019014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA190152"],"award-info":[{"award-number":["CA190152"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA210285"],"award-info":[{"award-number":["CA210285"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Plasma Epstein\u2010Barr virus (EBV) DNA measurement has established prognostic utility in EBV\u2010driven lymphomas, where it serves as a circulating tumor DNA marker. The value of plasma EBV measurement may be amplified in sub\u2010Saharan Africa (SSA), where advanced imaging and molecular technologies for risk stratification are not typically available. However, its utility in diffuse large B\u2010cell lymphoma (DLBCL) is less certain, given that only a subset of DLBCLs are EBV\u2010positive. To explore this possibility, we measured plasma EBV DNA at diagnosis in a cohort of patients with DLBCL in Malawi. High plasma EBV DNA at diagnosis (\u22653.0 log\n                    <jats:sub>10<\/jats:sub>\n                    copies\/mL) was associated with decreased overall survival (OS) (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.048). When stratified by HIV status, the prognostic utility of baseline plasma EBV DNA level was restricted to HIV\u2010positive patients. Unexpectedly, most HIV\u2010positive patients with high plasma EBV DNA at diagnosis had EBV\u2010negative lymphomas, as confirmed by multiple methods. Even in these HIV\u2010positive patients with EBV\u2010negative DLBCL, high plasma EBV DNA remained associated with shorter OS (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.014). These results suggest that EBV reactivation in nontumor cells is a poor prognostic finding even in HIV\u2010positive patients with convincingly EBV\u2010negative DLBCL, extending the potential utility of EBV measurement as a valuable and implementable prognostic marker in SSA.\n                  <\/jats:p>","DOI":"10.1002\/cam4.2710","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T09:47:51Z","timestamp":1575020871000},"page":"552-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["High pretreatment plasma Epstein\u2010Barr virus (EBV) DNA level is a poor prognostic marker in HIV\u2010associated, EBV\u2010negative diffuse large B\u2010cell lymphoma in Malawi"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1765-6623","authenticated-orcid":false,"given":"Nathan D.","family":"Montgomery","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of North Carolina Chapel Hill NC USA"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC USA"},{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of North Carolina Chapel Hill NC USA"},{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Painschab","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC USA"},{"name":"UNC Project\u2010Malawi Lilongwe Malawi"},{"name":"Department of Medicine Division of Hematology &amp; Oncology University of North Carolina Chapel Hill NC 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K.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avian","family":"Elliott","sequence":"additional","affiliation":[{"name":"UNC Healthcare Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa B.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coxcilly","family":"Kampani","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Chimzimu","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Mulenga","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blossom","family":"Damania","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC USA"},{"name":"Department of Microbiology &amp; Immunology University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamiwe","family":"Tomoka","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Fedoriw","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of North Carolina Chapel Hill NC USA"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC USA"},{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk P.","family":"Dittmer","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC USA"},{"name":"Department of Microbiology &amp; Immunology University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Gopal","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC USA"},{"name":"UNC Project\u2010Malawi Lilongwe Malawi"},{"name":"Department of Medicine Division of Hematology &amp; Oncology University of North Carolina Chapel Hill NC 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