{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:33:14Z","timestamp":1791070394610,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T00:00:00Z","timestamp":1401667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oncocytic L\u2010type amino acid transporter (<jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>) 1 may be a prognostic indicator and target of new molecular therapeutic agents against malignancies. To investigate whether <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>1 expression influence the outcomes of patients with bile duct cancer, the expression of <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>98, and Ki\u201067 was investigated immunohistochemically in 134 surgically resected bile duct adenocarcinomas, including 84 distal extrahepatic bile duct adenocarcinomas, 21 hilar cholangiocarcinomas, 15 intrahepatic cholangiocarcinomas, and 14 ampullary adenocarcinomas. <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>1 expression was weakly correlated with CD98 expression and Ki\u201067 labeling index (<jats:styled-content style=\"fixed-case\">LI<\/jats:styled-content>). Kaplan\u2013Meier analysis showed a significant difference in prognosis between patients with bile duct adenocarcinomas having <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>1\u2010high and \u2010low scores, whereas <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>98 expression and Ki\u201067 <jats:styled-content style=\"fixed-case\">LI<\/jats:styled-content> were not predictive of poor prognosis. Prognosis tended to be worse in patients having tumors with <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>1\u2010high\/<jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>2\u2010low than <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>1\u2010low\/<jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>2\u2010high scores (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0686). Multivariable analyses revealed that <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>1 expression, surgical margin, <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content> stage were independent prognostic factors. In conclusion, aberrant overexpression of <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>1 in bile duct adenocarcinoma predicts poor prognosis, suggesting that <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>1 may be a potential target of anticancer therapy.<\/jats:p>","DOI":"10.1002\/cam4.272","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T18:32:00Z","timestamp":1401733920000},"page":"1246-1255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["High expression of L\u2010type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas"],"prefix":"10.1002","volume":"3","author":[{"given":"Nobuyuki","family":"Yanagisawa","sequence":"first","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine Kanagawa 252\u20100374 Japan"},{"name":"Department of Pathology of Biological Responses Kitasato University Graduate School of Medical Science Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyomi","family":"Hana","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine Kanagawa 252\u20100374 Japan"},{"name":"J\u2010Pharma Co. 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Kanagawa 230\u20100046 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Nakada","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine Kanagawa 252\u20100374 Japan"},{"name":"Department of Pathology of Biological Responses Kitasato University Graduate School of Medical Science Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Ichinoe","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine Kanagawa 252\u20100374 Japan"},{"name":"Department of Pathology of Biological Responses Kitasato University Graduate School of Medical Science Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasaburo","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Endou","sequence":"additional","affiliation":[{"name":"J\u2010Pharma Co. 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Kanagawa 230\u20100046 Japan"},{"name":"Department of Pharmacology and Toxicology Kyorin University School of Medicine Tokyo 181\u20108611 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Okayasu","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Murakumo","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine Kanagawa 252\u20100374 Japan"},{"name":"Department of Pathology of Biological Responses Kitasato University Graduate School of Medical Science Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000251366.62632.d3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21238"},{"key":"e_1_2_7_4_1","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Bosman F. 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