{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:47Z","timestamp":1786977407541,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Esophageal squamous cell carcinoma (ESCC), head and neck SCC (HNSCC), and gastric adenocarcinoma (GA) are frequently detected at an early stage using endoscopic screening in Japanese alcohol\u2010dependent men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed endoscopic screening with esophageal iodine staining and oropharyngolaryngeal inspection in 7582 Japanese alcohol\u2010dependent men (40\u201079\u00a0years) during 1993\u20102018, and retrospectively investigated their initial screening results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 2008\u20102018 screening showed lower detection rates for ESCC (2.6% vs 4.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0009) and GA (0.5% vs 1.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001) for all age brackets, compared with the 1993\u20102007 screening. The HNSCC detection rate did not change (1.0% vs 1.1%). Multiple logistic regression analyses showed that the 2008\u20102018 screening had a reduced OR (95% CI) for ESCC (0.34 [0.25\u20100.47]) and GA (0.19 [0.10\u20100.35]), compared with the 1993\u20132007 screening. The reduction in\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection is probably the main reason for the decrease in GA detection over time. Declining trends in pack\u2010years and gastric atrophy and increasing trends in age and body mass index (BMI) were found over time. The presence of advanced gastric atrophy increased the risk for ESCC as well as GA. The inactive heterozygous\n                      <jats:italic>aldehyde dehydrogenase\u20102*1\/*2<\/jats:italic>\n                      genotype was a strong risk factor for ESCC, HNSCC, and GA. Fewer pack\u2010years and a larger BMI decreased the ESCC risk. However, these confounders cannot fully\u00a0explain why the incidence of ESCC has decreased markedly over the recent decade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The detection rates of ESCC and GA have markedly decreased during the past decade in the alcohol\u2010dependent population. The enigmatic declining trend of ESCC warrants research on this topic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.2737","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T06:22:28Z","timestamp":1575354148000},"page":"837-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Changing trends in cancer incidence of upper aerodigestive tract and stomach in Japanese alcohol\u2010dependent men (1993\u20102018)"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-1359","authenticated-orcid":false,"given":"Akira","family":"Yokoyama","sequence":"first","affiliation":[{"name":"National Hospital Organization Kurihama Medical and Addiction Center Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Omori","sequence":"additional","affiliation":[{"name":"Endoscopy Center Kawasaki Municipal Ida Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Health Promotion National Institute of Public Health Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.3.433"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26296"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0435"},{"key":"e_1_2_6_5_1","first-page":"99","article-title":"Esophageal cancer and aldehyde dehydrogenase\u20102 genotypes in Japanese males","volume":"5","author":"Yokoyama A","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04377.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.00908.x"},{"key":"e_1_2_6_8_1","unstructured":"National Tax Agency Taxation Department Liquor Tax and Industry Division.Sakenoshiori 2019(in Japanese).Tokyo:The Agency 2019: p 46."},{"key":"e_1_2_6_9_1","unstructured":"Ministry of Health Labor and Welfare.Kokumin Eiyo no Genjo 2017(The National nutrition survey in Japan 2017).Tokyo:Daiichi Publishing Co 2017; 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