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A favorable response to IFN has been argued to depend upon the tumor burden, implying that institution of treatment with IFN should be as early as possible after the diagnosis. However, evidence for this statement is not available. We present a thorough analysis of unique serial\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F measurements in 66 IFN\u2010treated patients and in 6 untreated patients. Without IFN treatment, the\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F allele burden increased exponentially with a period of doubling of 1.4\u00a0year. During monotherapy with IFN, the\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F allele burden decreased mono\u2010 or bi\u2010exponentially for 33 responders of which 28 patients satisfied both descriptions. Bi\u2010exponential description improved the fits in 19 cases being associated with late\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F responses. The decay of the\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F allele burden during IFN treatment was estimated to have half\u2010lives of 1.6\u00a0year for the monoexponential response and 1.0\u00a0year in the long term for the bi\u2010exponential response. In conclusion, through data\u2010driven analysis of the\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F allele burden, we provide novel information regarding the\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F kinetics during IFN\u2010treatment, arguing for early intervention.\n                  <\/jats:p>","DOI":"10.1002\/cam4.2741","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T17:27:09Z","timestamp":1580232429000},"page":"2039-2051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Data\u2010driven analysis of\n                    <i>JAK2<\/i>\n                    V617F kinetics during interferon\u2010alpha2 treatment of patients with polycythemia vera and related neoplasms"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5946-8220","authenticated-orcid":false,"given":"Rasmus K.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Science and Environment Roskilde University Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7582-0685","authenticated-orcid":false,"given":"Morten","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Science and Environment Roskilde University Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-3099","authenticated-orcid":false,"given":"Trine A.","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Haematology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9143-3092","authenticated-orcid":false,"given":"Zamra","family":"Sajid","sequence":"additional","affiliation":[{"name":"Department of Science and Environment Roskilde University Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4972-0653","authenticated-orcid":false,"given":"Johanne","family":"Gudmand\u2010Hoeyer","sequence":"additional","affiliation":[{"name":"Department of Science and Environment Roskilde University Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0096-9690","authenticated-orcid":false,"given":"Marc J. 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