{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:15:27Z","timestamp":1784074527996,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672680"],"award-info":[{"award-number":["81672680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802712"],"award-info":[{"award-number":["81802712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872375"],"award-info":[{"award-number":["81872375"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572665"],"award-info":[{"award-number":["81572665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To explore the prognostic value of early radiological response (ERR) to first\u2010line platinum\u2010containing chemotherapy in patients with metastatic nasopharyngeal carcinoma (mNPC), as well as its correlation with the best radiological response (BRR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A total of 756 mNPC patients with measurable lesions who received first\u2010line platinum\u2010containing chemotherapy were enrolled in this study. ERR was defined as complete or partial response after 6\u00a0weeks of chemotherapy according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. We performed survival analyses according to the radiological response after repeated chemotherapy. Log\u2010rank test and Cox regression were used to analyze the survival data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 470 patients achieved ERR and 78 patients achieved subsequent response (objective response after repeated chemotherapy). ERR patients had better OS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, median OS: 34.3 vs 22.2\u00a0months) and PFS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, median PFS: 10.2 vs 7.4\u00a0months) than non\u2010ERR ones. ERR (OS: HR\u00a0=\u00a00.591, 95% CI, 0.495\u20100.705, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, PFS: HR\u00a0=\u00a00.586, 95% CI, 0.500\u20100.686, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) was independently prolonged survival compared with non\u2010ERR ones. Besides, ERR was significantly correlated with the BRR (Kappa: 0.73; Pearson: 0.74, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and had significantly longer OS and PFS than patients with subsequent response, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ERR is an independent prognostic factor in determining survival in mNPC patients received first\u2010line platinum\u2010containing chemotherapy, which may be a more sensitive predictor to assess overall efficacy of systemic treatment than BRR in mNPC. Prospective validation studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2751","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T18:40:51Z","timestamp":1576262451000},"page":"920-930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic value of early radiological response to first\u2010line platinum\u2010containing chemotherapy in patients with metastatic nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-0669","authenticated-orcid":false,"given":"Guo\u2010Ying","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010Sen University Cancer Center Guangzhou China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010Sen University Cancer Center Guangzhou 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in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010Sen University Cancer Center Guangzhou China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010Sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010Sen University Cancer Center Guangzhou China"},{"name":"Imaging Diagnosis and Interventional Center Sun Yat\u2010Sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010Sen University Cancer Center Guangzhou China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010Sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4572-2018","authenticated-orcid":false,"given":"Kui\u2010Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010Sen University Cancer Center Guangzhou China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010Sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Hui","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010Sen University Cancer Center Guangzhou China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010Sen University Cancer Center Guangzhou 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